Reprogramming the brain with synthetic neurobiology.
Reprogramming the brain with synthetic neurobiology.
复制标题
用合成神经生物学重新编程大脑。
DOI：
10.1016/j.copbio.2018.10.013
复制
发表时间：
2019
影响因子：
7.7
通讯作者：
Ellington,Andrew
中科院分区：
文献类型：
--
作者：
Gardner,Elizabeth;Ellington,Andrew
HighlightsGenetic techniques may offer high-throughput solutions for problems in neuroscience.Greater resolution in cell-type selectivity can be achieved with a combination of single-cell RNA sequencing and intersectional targeting strategies.Combinatorial barcoding techniques allow tracking of neural projections.Neural activity can be tracked by genetically encoded indicators for fast fluorescent or transcriptional outputs.Engineering efforts yield novel ways to actuate neural signals with light or chemical effectors.Multicellular assemblies can be programmed by tools inspired by neurogenesis.The mammalian brain is among the most complex organs known in biology. Historically, neuroscience techniques have consisted primarily of low-throughput microscopy and electrophysiological approaches. While these methods will continue to serve the community, the emerging field of synthetic neurobiology may be better equipped to scale with systems neuroscience. By using genetic techniques to achieve cell-type specificity, a map of the connectome, neural activation and recording, and ultimately to program neural development itself, we can begin to build a better framework with which to understand the brain’s mechanisms.
