Small-volume frequency-domain oximetry: phantom experiments and first in vivo results.
Small-volume frequency-domain oximetry: phantom experiments and first in vivo results.
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小体积频域血氧测定法：模型实验和首次体内结果。
DOI：
10.1117/1.1608892
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发表时间：
2003
影响因子：
3.5
通讯作者：
H. Schwarzmaier
中科院分区：
文献类型：
--
作者：
S. Willmann;A. Terenji;J. Osterholz;J. Meister;P. Hering;H. Schwarzmaier
我们描述了一种新的方法，在小的源-探测器间隔(<；10 mm)下，绝对测定体内组织的血氧饱和度和总血红蛋白含量。在频域中测量了不同波长的调制激光在几个预定的源-探测器间隔下的相位和平均强度。根据这些测量量，利用改进的时间积分微观Beer-Lambert定律(MBL)推导出吸收系数。此外，利用人体皮肤的多层蒙特卡罗模型确定了光子的相互作用体积。为了评估该方法，我们使用了均匀的固体模体(由镶嵌在树脂中的二氧化钛颗粒组成)，其平均散射和吸收性能与人类皮肤相当。此外，对一名健康志愿者进行了活体测量，证明该技术适用于活体皮肤中氧饱和度和总血红蛋白含量的测定。该技术特别适用于需要小型涂抹器的应用(如胎儿血氧监测)中的血氧饱和度和总血红蛋白含量的在线测定。
We describe a new method to determine the oxygen saturation and the total hemoglobin content of tissue in vivo absolutely at small source-detector separations (<10 mm). Phase and mean intensity of modulated laser light of various wavelengths was measured at several predetermined source-detector separations in the frequency domain. From these measured quantities, the absorption coefficient was derived using the modified time-integrated microscopic Beer-Lambert law (MBL). In addition, the interaction volume of the photons was determined using a multi-layer Monte-Carlo model of human skin. To evaluate the method, we employed homogenous solid phantoms (consisting of TiO2 particles embedded in resin) with mean scattering and absorbing properties comparable to those of human skin. Furthermore, in vivo measurements were performed in a healthy volunteer to demonstrate that the technique is applicable for the determination of the oxygen saturation and the total hemoglobin content in the skin in vivo. The proposed technique is especially suited for the on-line determination of the oxygen saturation and total hemoglobin content in applications where small applicators are required (e.g., fetal oxygen monitoring sub partu).