Chemical carcinogenesis in the tracheobronchial epithelium.
Chemical carcinogenesis in the tracheobronchial epithelium.
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DOI：
10.1289/ehp.845577
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发表时间：
1984-04
影响因子：
10.4
通讯作者：
Harris CC
中科院分区：
文献类型：
--
作者：
Trump BF;McDowell EM;Harris CC
本文简要回顾了近年来在肺癌发生过程中的一些工作。人支气管肿瘤和癌前病变的形态学研究与仓鼠气管的癌变和上皮再生的类似研究进行了比较。这些研究表明，肺癌是典型的三种基本表型的复杂混合物，即表皮样表型和粘液和致密核心肉芽(内分泌)表型。这些表型的纯形式很少见，因为不同的细胞，甚至单个肿瘤中的单个细胞都表达不止一种表型。这种表型变异的临床意义尚不清楚。保留分裂能力的支气管细胞类型包括粘液细胞、基底细胞和致密核颗粒细胞。对上皮再生和癌前病变的研究表明，粘液细胞可能在损伤反应和癌变过程中起关键作用。吸烟被认为是肺癌的主要病因。香烟烟雾含有致癌物质，但也含有过多的可能的促进剂和致癌物质。据推测，香烟烟雾既可以启动支气管细胞，也可以促进以前由烟雾或其他因素启动的细胞癌变。进一步假设粘液细胞是启动和随后的肿瘤形成的主要靶点。肿瘤的最终表型(S)被认为是微环境因素对起始细胞及其后代的影响的结果。
Some of the recent work in pulmonary carcinogenesis is briefly reviewed. Morphologic studies of neoplastic and preneoplastic lesions of the human bronchi are compared with similar studies of carcinogenesis and epithelial regeneration in the hamster trachea. These studies suggest that bronchogenic carcinomas are typically complex mixtures of three basic phenotypes, the epidermoid and the mucous and dense-core granulated (endocrine) phenotypes. Pure forms of these phenotypes are rare, as different cells and even individual cells in single tumors express more than one phenotype. The clinical significance of such phenotypic variability is not yet known. Bronchial cell types which retain the capacity to divide include the mucous cell, the basal cell and perhaps the dense-core granulated cell. Studies of epithelial regeneration and preneoplastic lesions suggest that the mucous cell may be pivotal both in the response to injury and in carcinogenesis. Cigarette smoking is believed to be the major etiologic factor in bronchogenic carcinoma. Cigarette smoke contains initiators of carcinogenesis, but it contains a plethora of probable promoters and cocarcinogens as well. It is hypothesized that cigarette smoke may both initiate bronchial cells and promote carcinogenesis in cells which have previously been initiated by smoke or other factors. It is further hypothesized that that mucous cell is the major target for initiation and subsequent tumorigenesis. The ultimate phenotype(s) displayed by the tumor is suggested to result from the effect of microenvironmental factors upon the initiated cell and its progeny.