Genital schistosomiasis in women: a clinical 12-month in vivo study following treatment with praziquantel
Genital schistosomiasis in women: a clinical 12-month in vivo study following treatment with praziquantel
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DOI：
10.1016/j.trstmh.2005.09.010
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发表时间：
2006-08-01
影响因子：
2.2
通讯作者：
Gundersen, Svein Gunnar
中科院分区：
文献类型：
--
作者：
Kjetland, Eyrun F.;Mduluza, Takafira;Gundersen, Svein Gunnar
众所周知，尿路血吸虫病与女性生殖器官的损伤有关，特别是与塔状生殖道中的“沙斑”的存在有关。本研究旨在确定吡喹酮对血吸虫流行区居民妇科血吸虫病的治疗效果。在津巴布韦农村地区20-49岁的妇女中进行了一项队列研究。分别在治疗前、治疗后3个月和12个月绘制病灶的形状和大小图。在细胞学涂片、湿片、活组织检查、尿液和粪便中发现血瘤链球菌的卵子。采集的样本用于检测性传播疾病和癌症。在基线水平上，研究中包括的527名女性中，近一半有沙斑。虽然治疗后尿卵子排泄量减少(优势比10.3，95%CL3.8-27.8，P<；0.001)，但吡喹酮。治疗与生殖器损伤或接触性出血的显著减少无关(P=0.31-0.94)。即使在治疗后，沙斑仍与接触性出血和血管异常密切相关。研究结果与艾滋病毒状况无关。这种损害是常见的，至少12个月内显然无法治疗，可能是感染和传播艾滋病毒的重要风险因素。(C)2005年皇家热带医学和卫生学会。爱思唯尔有限公司出版。保留所有权利。
Urinary schistosomiasis is known to be associated with lesions in the female genital organs, particularly with the presence of 'sandy patches' in the tower genital tract. This study sought to determine the effect of treatment with praziquantel on gynaecological schistosomiasis in residents of an area endemic for Schistosoma haematobium. A cohort study was conducted among women aged 20-49 years in rural Zimbabwe. The shape and size of lesions were mapped pre treatment and 3 and 12 months following treatment. Ova of S. haematobium were Looked for in cytology smears, wet mounts, biopsies, urine and stool. Specimens were collected for detection of sexually transmitted diseases and cancer. At baseline, almost half of the 527 women included in the study had sandy patches. Although urinary ova excretion decreased following treatment (odds ratio 10.3, 95% Cl 3.8-27.8, P < 0.001), praziquantel. treatment was not associated with a significant reduction in genital lesions or contact bleeding (P= 0.31-0.94). Sandy patches remained strongly associated with contact bleeding and vessel abnormalities even after treatment. Findings were independent of HIV status. Such lesions, which are common and apparently refractory to treatment for at Least 12 months, may be an important risk factor for both the acquisition and transmission of HIV. (C) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.