Mammographic Breast Density in Chinese Women: Spatial Distribution and Autocorrelation Patterns.
Mammographic Breast Density in Chinese Women: Spatial Distribution and Autocorrelation Patterns.
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DOI：
10.1371/journal.pone.0136881
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Law HK
中科院分区：
文献类型：
--
作者：
Lai CW;Law HK
乳腺摄影乳腺密度（MBD）是乳腺癌的一个强有力的危险因素。MBD在乳房中的空间分布是可变的，并且取决于生理、遗传、环境和病理因素。本研究旨在探讨中国40-60岁女性MBD的空间分布和自相关模式。通过使用公共领域Java图像处理程序对他们的数字乳房X线摄影图像进行MBD分割和量化分析，我们发现他们的左右乳房在乳房大小（总乳房面积）、BMD量（总体PD）和Moran I值方面彼此对称。他们的MBD也是空间自相关在乳房的前部，在那些具有较小的乳房尺寸，而那些具有较大的乳房尺寸往往有他们的MBD聚集在乳房的后部附近。最后，我们观察到，MBD的自相关模式分散后，3年的观察期。
Mammographic breast density (MBD) is a strong risk factor for breast cancer. The spatial distribution of MBD in the breast is variable and dependent on physiological, genetic, environmental and pathological factors. This pilot study aims to define the spatial distribution and autocorrelation patterns of MBD in Chinese women aged 40–60. By analyzing their digital mammographic images using a public domain Java image processing program for segmentation and quantification of MBD, we found their left and right breasts were symmetric to each other in regard to their breast size (Total Breast Area), the amount of BMD (overall PD) and Moran's I values. Their MBD was also spatially autocorrelated together in the anterior part of the breast in those with a smaller breast size, while those with a larger breast size tend to have their MBD clustered near the posterior part of the breast. Finally, we observed that the autocorrelation pattern of MBD was dispersed after a 3-year observation period.