Accuracy of electroencephalographic dipole localization of epileptiform activities associated with focal brain lesions
Accuracy of electroencephalographic dipole localization of epileptiform activities associated with focal brain lesions
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DOI：
10.1002/ana.410440114
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发表时间：
1998-07-01
影响因子：
11.2
通讯作者：
Cosgrove, GR
中科院分区：
文献类型：
--
作者：
Krings, T;Chiappa, KH;Cosgrove, GR
我们评估了脑电图（EEG）定位技术（偶极子反解）在连续12例不同病因的局灶性脑病变中的准确性，这些病变的脑电图在癫痫发作时显示间歇峰活动或节律性活动。将计算得到的等效偶极子绘制在患者磁共振图像的三个轴上，假设病变的外壳构成致痫区，测量偶极子与病变边缘的距离。在所有病例中，偶极子定位在距离最近病变边缘0.8 cm以内。此外，我们比较了6例患者的术后结果与偶极子定位和切除边缘。在所有6例患者中，偶极子，因此估计癫痫发作的发生器，被移除手术结果是有利的。我们得出结论，反解算法是一种很有前途的方法，可以在常规临床脑电图中使用头皮脑电图来定位人脑电活动的来源，并提供传统分析无法获得的三维数据。
We evaluated the accuracy of an electroencephalographic (EEG) localization technique (dipole inverse solution) in a consecutive series of 12 focal intracerebral lesions of diverse etiologies whose EEGs showed interictal spike activity or rhythmic activity at seizure onset. The calculated equivalent dipole was plotted on three axes in the patients' magnetic resonance image, and the distance between the dipole and the lesion margin was measured assuming that the shell of the lesion constituted an epileptogenic region. In all cases the dipole localized closer than 0.8 cm to the nearest lesion margin. In addition, we compared the postsurgical outcome of 6 patients to the dipole localization and the resection margins. In all 6 patients in whom the dipole, and hence the estimated seizure generator, was removed the surgical outcome was favorable. We conclude that the inverse solution algorithm is a promising method for using the scalp EEG to localize the sources of electrical activity in the human brain in routine clinical electroencephalography and provides three-dimensional data not available from conventional analysis.