Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report
Successful neoadjuvant synchronous chemo- and radiotherapy for disseminated primary intracranial choriocarcinoma: case report
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DOI：
10.1007/s11060-006-9311-1
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发表时间：
2007-06-01
影响因子：
3.9
通讯作者：
Watanabe, Tsutomu
中科院分区：
文献类型：
--
作者：
Kageji, Teruyoshi;Nagahiro, Shinji;Watanabe, Tsutomu
我们报告了一名 17 岁男性，患有基底节播散性颅内绒毛膜癌，诊断时意识水平非常低。在彻底切除肿瘤之前，他接受了新辅助治疗（NAT），包括化疗和放疗联合治疗。术后接受了三个疗程的大剂量化疗（卡铂（CBDCA）、甲氨蝶呤（MTX）和依托泊苷（VP-16））和外周血干细胞移植。这种疗法的组合导致 MRI 上的肿瘤消退，并显着改善了他的神经系统状况。我们的报告首次报道了 NAT 后进行根治性手术对播散性原发性颅内绒毛膜癌患者的有效性。
We report a 17-year-old male with disseminated intracranial choriocarcinoma at the basal ganglia whose consciousness level was very low at diagnosis. He received neoadjuvant therapy (NAT) consisting of combined chemo- and radiotherapy prior to radical excision of the tumor. Postoperatively he was treated with three courses of high-dose chemotherapy (carboplatin (CBDCA), methotrexate (MTX), and etoposide (VP-16)) and peripheral blood stem-cell transplantation. This combination of therapies resulted in tumor regression on MRI and remarkable improvement in his neurological condition. Ours is the first report of the effectiveness of NAT followed by radical surgery in a patient with disseminated primary intracranial choriocarcinoma.