Neuroimaging correlates of aggression in schizophrenia: an update.
Neuroimaging correlates of aggression in schizophrenia: an update.
复制标题
精神分裂症攻击行为的神经影像学相关性：更新。
DOI：
10.1097/yco.0b013e328342c8e0
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发表时间：
2011-03
影响因子：
6.9
通讯作者：
Antonius D
中科院分区：
文献类型：
--
作者：
Hoptman MJ;Antonius D
精神分裂症患者的攻击行为与治疗效果差、住院和患者的污名化有关。因此，它是一个重要的公共卫生问题。本文综述了近年来精神分裂症攻击行为的神经影像学研究，重点是PET/单光子发射计算机断层扫描和MRI方法。关于精神分裂症攻击行为的神经影像学文献正处于发展阶段。这部分是由于这一侵略的性质和基础各不相同。放射学方法一直显示额叶和颞叶活动减少。MRI脑体积研究不太一致，一些研究发现下额叶结构体积增加，另一些研究发现精神分裂症患者的攻击性个体体积减少。功能性磁共振成像研究也有不一致的结果，大多数发现下额叶和颞叶区域的活动减少，但也有一些发现其他区域的活动增加。一些研究在反社会特征的背景下对精神分裂症的攻击类型进行了区分，这似乎有助于理解神经影像学文献。额叶和颞叶异常似乎是精神分裂症攻击性的一致特征，但由于这种行为的异质性，它们的确切性质可能有所不同。
Aggression in schizophrenia is associated with poor treatment outcomes, hospital admissions, and stigmatization of patients. As such it represents an important public health issue. This article reviews recent neuroimaging studies of aggression in schizophrenia, focusing on PET/single photon emission computed tomography and MRI methods. The neuroimaging literature on aggression in schizophrenia is in a period of development. This is attributable in part to the heterogeneous nature and basis of that aggression. Radiological methods have consistently shown reduced activity in frontal and temporal regions. MRI brain volumetric studies have been less consistent, with some studies finding increased volumes of inferior frontal structures, and others finding reduced volumes in aggressive individuals with schizophrenia. Functional MRI studies have also had inconsistent results, with most finding reduced activity in inferior frontal and temporal regions, but some also finding increased activity in other regions. Some studies have made a distinction between types of aggression in schizophrenia in the context of antisocial traits, and this appears to be useful in understanding the neuroimaging literature. Frontal and temporal abnormalities appear to be a consistent feature of aggression in schizophrenia, but their precise nature likely differs because of the heterogeneous nature of that behavior.