Chronic kidney disease: Fibrosis and anaemia in CKD--two beasts, one ancestor.
Chronic kidney disease: Fibrosis and anaemia in CKD--two beasts, one ancestor.
复制标题
慢性肾病：CKD 中的纤维化和贫血——两种野兽，一个祖先。
DOI：
10.1038/nrneph.2013.179
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Liu,Youhua
中科院分区：
文献类型：
--
作者：
Xiao,Liangxiang;Liu,Youhua
肾纤维化和贫血是进行性慢性肾病（CKD）的标志。新的证据表明，这些条件是密切相关的，因为损伤触发了肾促红细胞生成素生成细胞向纤维化肌成纤维细胞的表型转变。逆转这种转变的策略可能有望缓解CKD患者的贫血和纤维化。
Renal fibrosis and anaemia are hallmarks of progressive chronic kidney disease (CKD). New evidence demonstrates that these conditions are intimately connected, as injury triggers the phenotypic transition of renal erythropoietin-producing cells into fibrogenic myofibroblasts. Strategies to reverse such a transition may hold promise to alleviate both anaemia and fibrosis in CKD.