Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition
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DOI：
10.1101/gad.1363606
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发表时间：
2006-01-01
影响因子：
10.5
通讯作者：
Skarnes, WC
中科院分区：
文献类型：
--
作者：
Reiter, JF;Skarnes, WC
我们报告了一种新的蛋白质，参与刺猬介导的神经管图案的鉴定。这种蛋白质，命名为Tectonic，是以前未描述的进化保守的分泌和跨膜蛋白家族的创始成员。在神经管发育过程中，小鼠Tectonic是形成最腹侧细胞类型和完全激活Hedgehog（Hh）通路所必需的。上位性分析表明，构造调节Hh信号转导下游的Smoothened（Smo）和Rab23。有趣的是，构造Shh和构造Smo双突变体的表征表明，构造在抑制Hh途径活性中起着额外的作用。
We report the identification of a novel protein that participates in Hedgehog-mediated patterning of the neural tube. This protein, named Tectonic, is the founding member of a previously undescribed family of evolutionarily conserved secreted and transmembrane proteins. During neural tube development, mouse Tectonic is required for formation of the most ventral cell types and for full Hedgehog (Hh) pathway activation. Epistasis analyses reveal that Tectonic modulates Hh signal transduction downstream of Smoothened (Smo) and Rab23. Interestingly, characterization of Tectonic Shh and Tectonic Smo double mutants indicates that Tectonic plays an additional role in repressing Hh pathway activity.