Photoaging.
Photoaging.
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DOI：
10.1038/skinbio.2013.176
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发表时间：
2013-07-01
期刊：
影响因子：
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通讯作者：
Gilchrest, Barbara A
中科院分区：
文献类型：
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作者：
Gilchrest, Barbara A
光老化描述了在习惯性阳光暴露区域可以观察到的老年皮肤的临床、组织学和功能特征的变化。它由慢性阳光损伤（主要）叠加在所谓的内在或程序性老化。随着时间的推移，光老化造成了皮肤外观的大部分不必要的变化，并且还夸大或加速了生理储备和各种保护能力的丧失。光老化的重要性在于消费者对可以预防或逆转其印记的药物的巨大需求、其与皮肤恶性肿瘤的密切联系以及它提供的有关衰老本身本质的线索。
Photoaging describes those changes in clinical, histologic, and functional characteristics of older skin that can be observed in habitually sun-exposed areas. It consists of chronic sun damage (predominantly) superimposed on so-called intrinsic or programmed aging. Photoaging accounts for most of the unwanted changes in skin appearance over time and also exaggerates or accelerates the loss of physiologic reserve and various protective capacities. The importance of photoaging lies in the enormous consumer demand for agents that can prevent or reverse its stigmata, its strong association with cutaneous malignancies, and the clues it provides regarding the nature of aging itself.