Cardiac Structure-Function MRI in Patients After Heart Transplantation.
Cardiac Structure-Function MRI in Patients After Heart Transplantation.
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DOI：
10.1002/jmri.26275
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Carr JC
中科院分区：
文献类型：
--
作者：
Dolan RS;Rahsepar AA;Blaisdell J;Lin K;Suwa K;Ghafourian K;Wilcox JE;Khan SS;Vorovich EE;Rich JD;Anderson AS;Yancy CW;Collins JD;Markl M;Carr JC
在心脏移植（Tx）后，受者通过心肌膜活检（受成本和侵入性限制）和超声心动图（在详细的结构和功能评估方面受到限制）密切监测。目的：验证综合结构-功能心脏MRI作为一种无创方式评估心肌结构和功能变化的可行性。未来的。对61例心脏移植受者（年龄47.9±16.3岁，女性39%）和14例年龄匹配的健康对照（年龄47.7±16.7岁，女性36%）进行磁共振检查。1.5 t;二维CINE稳态自由进动（SSF）P成像、t2成像、钆前后对比t1成像和组织相位成像（TPM）。量化心肌T2（作为水肿的测量），gd前后T1（允许计算细胞外体积（ECV）来估计间质扩张），以及基于tpm的区域左室（LV）峰值速度、非同步化和扭转的评估。采用独立样本t检验对移植受者和对照组进行比较。使用Pearson相关分析评估结构（T2、T1、ECV）和功能指标（心肌速度、非同步化、扭转）之间的关系。与对照组相比，移植受者T2和T1显著升高（整体T2: 50.5±3.4 msec vs. 45.2±2.3 msec, P < 0.01；整体T1: 1037.8±48.0 msec vs. 993.8±34.1 msec, P < 0.01）。与对照组相比，移植受者的收缩纵向功能受损（收缩纵向速度峰值降低，2.9±1.1 cm/s vs 5.1±1.2 cm/s, P < 0.01；收缩纵向不同步性升高，60.2±30.2 msec vs 32.1±25.1 msec, P < 0.01）。相关分析显示T2与ECV呈正相关（r = 0.45,P < 0.01）。此外，收缩纵向速度峰值与T2呈显著负相关（总体r = - 0.29, P = 0.02），收缩径向非同步化与T2和T1峰值呈正相关（r = 0.26,P = 0.04; r = 0.27,P = 0.03）。与对照组相比，MR技术对移植受体的结构和功能差异敏感。结构（T2, T1）和功能（峰值心肌速度，非同步化）指标显著相关，表明心脏移植后心脏异常存在结构-功能关系。
Following heart transplantation (Tx), recipients are closely monitored using endomyocardial biopsy, which is limited by cost and invasiveness, and echocardiography, which is limited regarding detailed structural and functional evaluation. To test the feasibility of comprehensive structure-function cardiac MRI as a noninvasive modality to assess changes in myocardial structure and function. Prospective. MR was performed in 61 heart transplant recipients (age 47.9 ± 16.3 years, 39% female) and 14 age-matched healthy controls (age 47.7 ± 16.7 years, 36% female). 1.5T; 2D CINE steady state free precession (SSF)P imaging, T2-mapping, pre- and postgadolinium contrast T1-mapping, and tissue-phase mapping (TPM). Quantification of myocardial T2 (as a measure of edema), pre- and post-Gd T1 (allowing calculation of extracellular volume (ECV) to estimate interstitial expansion), and TPM-based assessment of peak regional left ventricular (LV) velocities, dyssynchrony, and twist. Comparisons between transplant recipients and controls were performed using independent samples t-tests. Relationships between structural (T2, T1, ECV) and functional measures (myocardial velocities, dyssynchrony, twist) were assessed using Pearson correlation analysis. T2 and T1 were significantly elevated in transplant recipients compared to controls (global T2: 50.5 ± 3.4 msec vs. 45.2 ± 2.3 msec, P < 0.01; global T1: 1037.8 ± 48.0 msec vs. 993.8 ± 34.1 msec, P < 0.01). Systolic longitudinal function was impaired in transplant recipients compared to controls (reduced peak systolic longitudinal velocities, 2.9 ± 1.1 cm/s vs. 5.1 ± 1.2 cm/s, P < 0.01; elevated systolic longitudinal dyssynchrony, 60.2 ± 30.2 msec vs. 32.1 ± 25.1 msec, P < 0.01). Correlation analysis revealed a significant positive relationship between T2 and ECV (r = 0.45,P < 0.01). In addition, peak systolic longitudinal velocities demonstrated a significant inverse relationship with T2 (global r = −0.29, P = 0.02), and systolic radial dyssynchrony was positively associated with peak T2 and peak T1 (r = 0.26,P = 0.04; r = 0.27,P = 0.03). MR techniques are sensitive to structural and functional differences in transplant recipients compared to controls. Structural (T2, T1) and functional (peak myocardial velocities, dyssynchrony) measures were significantly associated, suggesting a structure-function relationship of cardiac abnormalities following heart transplant.
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DOI：
10.1186/s12968-014-0052-6
发表时间：
2014-07-20
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Miller CA;Naish JH;Shaw SM;Yonan N;Williams SG;Clark D;Bishop PW;Ainslie MP;Borg A;Coutts G;Parker GJ;Ray SG;Schmitt M
通讯作者：
Schmitt M
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
9.7
作者：
Lampert, Brent C.;Teuteberg, Jeffrey J.;Smith, Kenneth J.
通讯作者：
Smith, Kenneth J.
影响因子：
24
作者：
Miller, Christopher A.;Sarma, Jaydeep;Schmitt, Matthias
通讯作者：
Schmitt, Matthias
影响因子：
3.3
作者：
Jung, Bernd;Honal, Matthias;Markl, Michael
通讯作者：
Markl, Michael