Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis
Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis
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DOI：
10.1016/j.biopsych.2008.04.030
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发表时间：
2008-10-01
影响因子：
10.6
通讯作者：
Cohen, David
中科院分区：
文献类型：
--
作者：
Amiet, Claire;Gourfinkel-An, Isabelle;Cohen, David
背景：癫痫和孤独症之间的关联一直被报道，患病率范围很广。这可能归因于样本在年龄、合并症、性别和智力残疾（ID）方面的异质性。我们的目的是比较1）患有ID的自闭症患者与没有ID的自闭症患者之间以及2）男性与女性自闭症患者之间癫痫的患病率。方法：我们回顾了所有已发表报告中的数据（1963-2006）关于自闭症和癫痫的研究，并分别对10项和14项研究进行了荟萃分析，根据ID和性别评估自闭症患者癫痫的相对风险（RR）。结果：根据智商的不同，相对危险度（RR）存在很大的差异，更多的孤独症患者患有癫痫（RR = .555; 95%可信区间[CI]：.42-.73; P <0.01）。
Background: The association between epilepsy and autism is consistently reported, with a wide range of prevalence rates. This may be attributed to the heterogeneity of the samples with respect to age, comorbidity, sex, and intellectual disability (ID). We aimed to compare the prevalence of epilepsy 1) among autistic patients with ID versus autistic patients without ID and 2) among male versus female autistic patients.Methods: We reviewed all data available from published reports (1963-2006) on autism and epilepsy and conducted a meta-analysis of 10 and 14 studies, respectively, to assess the relative risk (RR) of epilepsy in autism according to ID and gender. The pooled groups included 2112 (627 with IQ : 70, 1485 with IQ < 70) and 1530 (1191 male, 339 female) patients, respectively.Results: There was a strong discrepancy in relative risk (RR) according to IQ, with more autistic patients with ID having epilepsy (RR = .555; 95% confidence interval [CI]:.42-.73; p