Alterations in Hippocampal Activity and Alzheimer's Disease.
Alterations in Hippocampal Activity and Alzheimer's Disease.
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DOI：
10.1037/tps0000124
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发表时间：
2017-12
影响因子：
1.8
通讯作者：
Reed MN
中科院分区：
文献类型：
--
作者：
Setti SE;Hunsberger HC;Reed MN
老年人和遗忘型轻度认知障碍（aMCI）患者患阿尔茨海默病（AD）的风险增加。特别是患有aMCI的个体可能会显示出脑功能的病理变化，最终可能导致AD的诊断。这篇综述特别关注海马过度兴奋，这是一种在诊断前几年就可以检测到的病理，在aMCI患者中已经观察到。我们描述了海马活动的变化是如何与AD的发展相关的，或者在某些情况下可能是允许的。最后，我们描述了生活方式的改变，包括运动和饮食的改变，可以减轻认知能力下降和海马过度兴奋，潜在地降低AD的风险。
The aging population and those with amnestic mild cognitive impairment (aMCI) are at increased risk for developing Alzheimer’s disease (AD). Individuals with aMCI in particular may display pathological changes in brain function that may ultimately result in a diagnosis of AD. This review focuses specifically on hippocampal hyperexcitability, a pathology that is sometimes detectable years before diagnosis, which has been observed in individuals with aMCI. We describe how changes in hippocampal activity are associated with, or in some cases may be permissive for, the development of AD. Finally, we describe how lifestyle changes, including exercise and dietary changes can attenuate cognitive decline and hippocampal hyperexcitability, potentially reducing the risk of developing AD.