Silver-Mediated C - S Cross-Coupling of Di(pyrimidin-2-yl) Disulfides with Aliphatic Carboxylic Acids
Silver-Mediated C - S Cross-Coupling of Di(pyrimidin-2-yl) Disulfides with Aliphatic Carboxylic Acids
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银介导的二(嘧啶-2-基)二硫化物与脂肪族羧酸的C-S交叉偶联
DOI：
10.1002/slct.201601870
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发表时间：
2017
期刊：
影响因子：
2.1
通讯作者：
Wang Xi-Cun
中科院分区：
文献类型：
--
作者：
Wang Wen-Juan;Liu Xiao-Jun;Wang Xi-Cun
报道了一种银介导的脂肪族羧酸的脱羧交叉偶联，以提供C-S偶联产物。该反应在温和的条件下顺利进行，并耐受各种1，2-二（嘧啶-2-基）二硫化物和带有供电子和吸电子基团的脂肪族羧酸。这为烷基嘧啶硫醚的合成提供了一种新的途径，烷基嘧啶硫醚可作为药物合成的关键中间体。
A silver‐mediated decarboxylative cross‐coupling of aliphatic carboxylic acids to deliver C−S couplings products is reported. This reaction occurs smoothly under mild conditions and tolerates a various 1,2‐di(pyrimidin‐2‐yl)disulfides and aliphatic carboxylic acids bearing both electron‐donating and electron‐withdrawing groups. It provides an alternative approach for the synthesis of alkyl pyrimidinyl sulfides, which may be applied as the key intermediates in the synthesis of drug candidates.