Waist-height ratio as a predictor of coronary heart disease among women.
Waist-height ratio as a predictor of coronary heart disease among women.
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DOI：
10.1097/ede.0b013e31819f38f1
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Manson JE
中科院分区：
文献类型：
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作者：
Page JH;Rexrode KM;Hu F;Albert CM;Chae CU;Manson JE
我们研究的目的是前瞻性地评估和比较腰围/身高比(WHtR)/腰臀比、腰围和体重指数作为一组主要为绝经后妇女的冠心病(CHD)的预测因子。这些数据来自一项前瞻性队列研究。纳入的研究对象是1986年护士健康研究队列中的45563名年龄在40-65岁之间的女性，她们没有心脏病、中风和癌症。通过问卷调查收集腰围、臀围、身高、体重、年龄等协变量。主要终点是2002年6月报告的冠心病事件。对每个人体测量指标的受试者工作特征曲线(AUC)下面积进行非参数估计，并估计WHtR与其他指标之间的差异以及相应的95%可信区间。用COX比例风险模型估计与冠心病风险的关系。腰高比、腰臀比和腰围在预测随后发生冠心病的风险方面相似。在预测冠心病方面，三项腰围测量指标均优于BMI。未调整的AUC(95%可信区间)为0.62(0.60，0.64)，腰臀比为0.63(0.61，0.65)，腰围为0.62(0.60，0.64)，体重指数为0.57(0.55，0.59)。在预测中老年女性冠心病发病率方面，腰高比与腰围和腰臀比相当，但优于BMI。未来的研究有必要在其他人群中证实这些结果。
The aim of our study is to prospectively evaluate and compare the waist circumference-to-height ratio (WHtR) to waist-hip ratio, waist circumference, and body mass index as predictors of subsequent coronary heart disease (CHD) in a group of predominantly post-menopausal women. The data comes from a prospective cohort study. The included subjects were 45563 women from the Nurses' Health Study cohort, aged 40-65 years in 1986, who were free of heart disease, stroke and cancer. Waist circumference, hip circumference, height, weight, age, and other covariates were collected by questionnaire. The primary endpoint was incident coronary heart disease that was reported by June 2002. Areas under the receiver operating characteristic curves (AUC) were estimated non-parametrically for each of anthropometric measures, and differences between that for WHtR and the other measures, and corresponding 95% confidence intervals were estimated. Cox proportional hazard models were used to estimate the relationships with risk of CHD. Waist-height ratio, waist-hip ratio and waist circumference were similar in predicting subsequent risk of CHD. All three waist derived measures were superior to BMI in predicting CHD. The unadjusted AUC (95% Confidence Interval) were 0.62 (0.60,0.64) for WHtR, 0.63 (0.61,0.65) for waist-hip ratio, 0.62 (0.60,0.64) for waist-circumference, and 0.57 (0.55,0.59) for body mass index. Waist-height ratio is comparable to waist circumference and waist-hip ratio for prediction of coronary heart disease incidence among middle-aged and older women, but superior to BMI. Future studies are warranted to corroborate these results in other populations.