Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
Obsessive-compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
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DOI：
10.1016/j.psychres.2005.03.003
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发表时间：
2005-06-15
影响因子：
11.3
通讯作者：
Murphy, DL
中科院分区：
文献类型：
--
作者：
Hasler, G;LaSalle-Ricci, VH;Murphy, DL
本研究的目的是检查强迫症 (OCD) 症状类别之间的关系，通过因子分析和聚类分析建立 OCD 症状维度，并探讨 OCD 症状维度与共病神经精神疾病之间的关联。共有 3 17 名强迫症参与者接受了系统诊断访谈，使用 DSM-IV 强迫症症状结构化临床访谈，通过耶鲁布朗强迫量表症状检查表（N = 169）和思想和行为量表（N = 275）进行评估，并接受因子和聚类分析。来自重叠样本的两个不同数据集中出现了相同的四因素解决方案，与大多数仅使用 YBOCS 检查表的小型因素分析研究不一致。聚类分析证实了四因素解决方案，并提供了有关五个不同级别强迫症症状类别之间相似性的附加信息。强迫症症状维度显示出与共病精神疾病的特定关系：因子 I（攻击性、性、宗教和躯体强迫观念以及检查强迫行为）与共病焦虑症和抑郁症广泛相关；患有双相情感障碍和恐慌症/广场恐惧症的因子 II（对对称性的痴迷，以及重复、计数和排序/排列强迫症）；因素III（污染强迫症和清洁强迫症）与饮食失调有关。因素 I 和 II 与早发强迫症有关。本研究鼓励使用聚类分析作为因素分析的补充方法来确定精神症状维度。强迫症与其他精神疾病频繁共存，以及强迫症症状维度与共存疾病之间相对具体的关联模式支持强迫症亚型对于这种异质性疾病的治疗、遗传和其他研究的重要性。 (c) 2005 年，爱思唯尔爱尔兰有限公司出版。
The goals of this study were to examine relationships among symptom categories in obsessive-compulsive disorder (OCD), to establish OCD symptom dimensions by factor- and cluster-analytic analyses, and to explore associations between OCD symptom dimensions and comorbid neuropsychiatric conditions. A total of 3 17 OCD participants underwent a systematic diagnostic interview using the Structured Clinical Interview for DSM-IV OCD symptoms assessed by the Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (N= 169) and by the Thoughts and Behaviors Inventory (N=275) were Subjected to factor and cluster analyses. An identical four-factor solution emerged in two different data sets from overlapping samples, ill agreement with most smaller factor-analytic studies employing the YBOCS checklist alone. The cluster analysis confirmed the four-factor solution and provided additional information on the similarity among OCD symptom categories at five different levels. OCD symptom dimensions showed specific relationships to comorbid psychiatric disorders: Factor I (aggressive, sexual, religious and somatic obsessions, and checking compulsions) was broadly associated with comorbid anxiety disorders and depression; FactorII (obsessions of symmetry, and repeating, counting and ordering/arranging compulsions) with bipolar disorders and panic disorder/agoraphobia; and Factor III (contamination obsessions and cleaning compulsions) with eating disorders. Factors I and II were associated with early onset OCD. This study encourages the use of cluster analyses as a supplementary method to factor analyses to establish psychiatric symptom dimensions. The frequent co-occurrence of OCD with other psychiatric disorders and the relatively specific association patterns between OCD symptom dimensions and comorbid disorders support the importance of OCD subtyping for treatment, genetic, and other research studies of this heterogeneous disorder. (c) 2005 Published by Elsevier Ireland Ltd.