Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder
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DOI：
10.1016/j.neuroimage.2011.02.064
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Lanzenberger, Rupert
中科院分区：
文献类型：
--
作者：
Hahn, Andreas;Stein, Patrycja;Lanzenberger, Rupert
社交焦虑症患者在社交互动中存在过度焦虑反应，导致回避行为和社交损害。虽然杏仁核在感知和处理威胁线索方面起着中心作用，但人们对社交焦虑中涉及的网络和相应的功能障碍知之甚少。因此，本研究旨在研究社交焦虑症患者杏仁核的功能连接网络，以确定可能通过调节通路影响杏仁核反应性的区域。10名焦虑症患者(社交和/或惊恐)和27名健康对照组在安静状态下接受了面部情绪处理任务和6分钟功能磁共振成像。以杏仁核为种子区计算个体体素功能连接图。采用SPM的随机效应分析进行组间比较，患者在情绪任务中杏仁核过度激活，左侧杏仁核与内侧眶前叶皮质和扣带回后叶/楔前叶的功能耦合减弱。这种功能连接的强度与状态焦虑的严重程度呈负相关。此外，一项探索性分析显示，在患者组中，内侧眶前叶和前扣带回皮质之间的功能连接进一步减少和明显分离。我们的结果表明，社交焦虑障碍患者杏仁核功能连接网络发生了变化。结合杏仁核的过度激活，我们的研究结果证实了焦虑症患者的额叶-杏仁核抑制功能障碍，并表明前扣带回和后扣带回皮质对威胁感知和处理的调节影响。(C)2011 Elsevier Inc.保留所有权利。
Social anxiety disorder patients suffer from excessive anxious responses in social interaction leading to avoidance behavior and social impairment. Although the amygdala has a central role in perception and processing of threatening cues, little is known about the involved networks and corresponding dysfunctions in social anxiety. Therefore, this study aims to investigate the functional connectivity network of the amygdala in patients with social anxiety disorder and to identify regions that might influence amygdalar reactivity via modulatory pathways.Ten patients with anxiety disorders (social and/or panic) and 27 healthy controls underwent a facial emotion processing task as well as 6-min functional MRI at resting state. Individual voxel-wise functional connectivity maps were calculated using the amygdala as seed region. Group comparisons were done by random-effects analysis in SPM.Patients exhibited an amygdala hyperactivation during the emotional task and decreased functional coupling of the left amygdala With the medial orbitofrontal cortex and the posterior cingulate cortex/precuneus. The strength of this functional connectivity showed a negative association with the severity of state anxiety. In addition, an exploratory analysis revealed further reduced functional connectivity and a marked functional separation between the medial orbitofrontal and anterior cingulate cortices in the patient group.Our results suggest alterations within the amygdalar functional connectivity network in social anxiety disorder. Combined with the amygdalar hyperactivation our findings corroborate the proposed dysfunction of the fronto-amygdalar inhibition in anxiety disorders and indicate a modulatory influence of the anterior and posterior cingulate cortices on threat perception and processing. (C) 2011 Elsevier Inc. All rights reserved.