Intravitreal erythropoietin injection in late-stage optic neuropathy: a safety study on human
Intravitreal erythropoietin injection in late-stage optic neuropathy: a safety study on human
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DOI：
10.1007/s10792-017-0553-z
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发表时间：
2018-06-01
影响因子：
1.6
通讯作者：
Sobaci, Gungor
中科院分区：
文献类型：
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作者：
Acar, Ugur;Kucuk, Bekir;Sobaci, Gungor
评价玻璃体内注射促红细胞生成素（EPO）对晚期视神经病变（ON）患者是否有有利或不利的影响。该研究检查了16名晚期ON患者的16只眼睛，受影响的眼睛的最佳矫正视力（BCVA）为ae1/20。其中，非动脉缺血性ON 10眼（62.5%），外伤性ON 4眼（25.0%），甲醇性ON 2眼（12.5%）。采用pars plana入路，用30号针静脉滴注2000 IU/0.2 ml EPO。注射三次，间隔6周。我们比较了初始检查和最终检查时BCVA、眼内压（IOP）、视网膜神经纤维层（RNFL）厚度、模式视觉诱发电位（p-VEP）和模式视网膜电图（p-ERG）参数的差异。患者平均年龄52.38±12.00岁；其中女性2例（12.50%），男性14例（87.50%）。16例视神经萎缩患者初始检查时的平均BCVA水平为1.12 +/- 0.25 logMAR，终末检查时的平均BCVA水平为1.08 +/- 0.26 logMAR （p = 0.102）。初始和最终RNFL厚度、IOP值、p-ERG或p-VEP反应之间无统计学差异。玻璃体内注射促生成素对晚期on无有益或有害影响。需要进一步的研究来比较我们在早期ON患者中的结果。
To evaluate the whether intravitreal erythropoietin (EPO) administration has any beneficial or adverse effect in patients with late-stage optic neuropathy (ON) or not.The study examined 16 eyes of 16 patients who had late-stage ON and ae1/20 best-corrected visual acuity (BCVA) in their affected eye. There were nonarteritic ischemic ON in 10 (62.5%) eyes, traumatic ON in 4 (25.0%) eyes and methanol-induced ON in 2 (12.5%) eyes. Using pars plana approach, 2000 IU/0.2 ml EPO was administered intravitreally with a 30-gauge needle. Injections were administered three times with 6-week intervals. We compared the differences in the BCVA, intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, pattern visual evoked potentials (p-VEP) and pattern electroretinography (p-ERG) parameters performed at initial examination and final visits.The mean age of the patients was 52.38 +/- 12.00 years; 2 (12.50%) of them were female, and 14 (87.50%) of them were male. The mean BCVA levels of 16 patients with optic atrophy were 1.12 +/- 0.25 logMAR at the initial examination and 1.08 +/- 0.26 logMAR at the final visit (p = 0.102). There was no statistically significant difference between the initial and final RNFL thicknesses, IOP values, p-ERG or p-VEP responses.Intravitreal EPO injections have no beneficial or detrimental effect on the late stage of ON. Further studies are necessary to compare our results in patients with ON in earlier stages.