Low serum micronutrient concentrations predict frailty among older women living in the community
Low serum micronutrient concentrations predict frailty among older women living in the community
复制标题
DOI：
10.1093/gerona/61.6.594
复制
发表时间：
2006-06-01
影响因子：
5.1
通讯作者：
Fried, Linda P.
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Bartali, Benedetta;Fried, Linda P.
背景。微量营养素缺乏在老年人中很常见。我们假设低血清微量营养素浓度是生活在社区的老年残疾妇女虚弱的预测指标。我们研究了766名年龄在65岁及以上的妇女，来自妇女健康和老龄化研究1，这是一项基于人群的研究，研究对象是马里兰州巴尔的摩市的中度至重度残疾社区妇女。血清维生素A、D、E、B-6和B-12、类胡萝卜素、叶酸、锌和硒在基线时测定。在基线和3年随访期间的年度访问中确定虚弱状态。在基线时，250名女性身体虚弱，516名女性不虚弱。在463名至少进行一次随访的非虚弱女性中，205名（31.9%）变得虚弱，总发病率为19.1 / 100人年。与上四分位数的女性相比，血清类胡萝卜素（风险比[HR] 1.39； 95%可信区间[Cl]， 1.01-1.92）、α -生育酚（风险比[HR] 1.39； 95%可信区间[Cl]， 1.02-1.92）和25-羟基维生素D（风险比[HR] 1.34； 95%可信区间[Cl]， 0.94-1.90）最低四分位数的女性变得虚弱的风险增加。在调整年龄、吸烟状况和慢性肺部疾病后，营养缺乏的数量（HR 1.10; 95% Cl, 1.01-1.20）与变得虚弱的风险增加相关。调整潜在的混杂因素后，我们发现血清类胡萝卜素含量最低四分之一的女性变得虚弱的风险更高（HR 1.54; 95% Cl, 1.11-2.13）。血清微量营养素浓度低是残疾老年妇女虚弱的独立危险因素，并且随着微量营养素缺乏的数量增加，虚弱的风险增加。
Background. Micronutrient deficiencies are common among older adults. We hypothesized that low serum micronutrient concentrations were predictive of frailty among older disabled women living in the community.Methods. We studied 766 women, aged 65 and older, from the Women's Health and Aging Study 1, a population-based study of moderately to severely disabled community-dwelling women in Baltimore, Maryland. Serum vitamins A, D, E, B-6, and B-12, carotenoids, folate, zinc, and selenium were measured at baseline. Frailty status was determined at baseline and during annual visits for 3 years of follow-up.Results. At baseline, 250 women were frail and 516 women were not frail. Of 463 nonfrail women who had at least one follow-up visit, 205 (31.9%) became frail, with an overall incidence rate of 19.1 per 100 person-years. Compared with women in the upper three quartiles, women in the lowest quartile of serum carotenoids (hazard ratio [HR] 1.39; 95% confidence interval [Cl], 1.01-1.92), alpha-tocopherol (HR 1.39; 95% Cl, 1.02-1.92), and 25-hydroxyvitamin D (HR 1.34; 95% Cl, 0.94-1.90) had an increased risk of becoming frail. The number of nutritional deficiencies (HR 1.10; 95% Cl, 1.01-1.20) was associated with an increased risk of becoming frail, after adjusting for age, smoking status, and chronic pulmonary disease. Adjusting for potential confounders, we found that women in the lowest quartile of serum carotenoids had a higher risk of becoming frail (HR 1.54; 95 % Cl, 1.11-2.13).Conclusions. Low serum micronutrient concentrations are an independent risk factor for frailty among disabled older women, and the risk of frailty increases with the number of micronutrient deficiencies.