MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
MicroRNA-155-at the Critical Interface of Innate and Adaptive Immunity in Arthritis.
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DOI：
10.3389/fimmu.2017.01932
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发表时间：
2017
影响因子：
7.3
通讯作者：
Kurowska-Stolarska M
中科院分区：
文献类型：
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作者：
Alivernini S;Gremese E;McSharry C;Tolusso B;Ferraccioli G;McInnes IB;Kurowska-Stolarska M
microRNA（miRNAs）是一种小的非编码RNA，通过调节细胞转录组来微调细胞对变化的环境的反应。miR-155是在免疫系统细胞中富集的多功能miRNA，并且对于免疫应答是必不可少的。然而，当去调控时，miR-155有助于慢性炎症、自身免疫、癌症和纤维化的发展。在此，我们回顾了miR-155在类风湿关节炎中驱动免疫系统异常激活的致病作用的证据，以及其作为疾病生物标志物和治疗靶点的潜力。
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune response. However, when deregulated, miR-155 contributes to the development of chronic inflammation, autoimmunity, cancer, and fibrosis. Herein, we review the evidence for the pathogenic role of miR-155 in driving aberrant activation of the immune system in rheumatoid arthritis, and its potential as a disease biomarker and therapeutic target.