Dose rate dependence of response of mouse lung to irradiation.
Dose rate dependence of response of mouse lung to irradiation.
复制标题
小鼠肺对辐射反应的剂量率依赖性。
DOI：
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复制
发表时间：
1985
影响因子：
2.6
通讯作者：
W. Rybka
中科院分区：
文献类型：
--
作者：
S. Lehnert;W. Rybka
以LD_（50）/（50-180）作为放射性肺炎发生率的指标，研究了小鼠肺损伤的剂量率依赖性。以100、25和6 cGy/min的速度对胸部进行60 Co γ辐射的平均致死剂量分别为1403、1923和2488 cGy。在6和25 cGy/min下获得的值之间以及在25和100 cGy/min下获得的值之间存在统计学显著性差异。该数据在对数-对数图上的等效应图显示，剂量率降低对肺的节省效应大于更快速响应的系统（培养中的小肠和中国仓鼠细胞的集落形成单位）。
The dose-rate dependence of lung damage in mice has been studied using LD50/50-180 as an index of the incidence of radiation pneumonitis. Mean lethal doses for 60Co gamma radiation to the thorax delivered at 100, 25 and 6 cGy/min were 1403, 1923 and 2488 cGy respectively. There were statistically significant differences between values obtained at 6 and 25 cGy/min and between those obtained at 25 and 100 cGy/min. An isoeffect plot of this data on a log-log graph shows the sparing effect of dose rate reduction to be greater for the lung than for more rapidly responding systems (colony forming units of small intestine and Chinese hamster cells in culture).
DOI：
10.1016/0360-3016(82)90517-x
发表时间：
1982-01-01
影响因子：
7
作者：
THAMES, HD;WITHERS, HR;FLETCHER, GH
通讯作者：
FLETCHER, GH