Functional connectivity of limbic system and prefrontal cortex years after pre-eclampsia: 7-Tesla functional magnetic resonance imaging study
Functional connectivity of limbic system and prefrontal cortex years after pre-eclampsia: 7-Tesla functional magnetic resonance imaging study
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DOI：
10.1002/uog.24928
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发表时间：
2022-09-12
影响因子：
7.1
通讯作者：
Backes, W. H.
中科院分区：
文献类型：
--
作者：
Canjels, L. P. W.;Ghossein-Doha, C.;Backes, W. H.
目的子痫前期是妊娠期的一种血管并发症，长期存在脑血管和精神障碍的危险。我们探讨了先兆子痫妇女在大脑功能组织方面的差异，特别是在可能解释怀孕多年后常见的情感症状和认知主诉的区域。方法对先兆子痫妇女和有正常血压孕产史的对照组妇女进行结构和功能7-TESLA磁共振成像扫描。利用图论分析方法，研究了功能脑网络的效率和聚类系数。这项研究包括专注于特定大脑结构的局部分析，如边缘系统和前额叶皮质，以及整个大脑的整体分析。采用单因素线性回归和多元线性回归分析脑网络相关脑图指标与子痫前期组和对照组的关系。结果共纳入17例对照产妇和5S例有子痫前期病史的产妇。两组从怀孕到招募的时间间隔分别为8.0年和S.6年。与对照组相比，先兆子痫患者在前额叶(P=0.048)和前扣带回(P=0.03)的局部有效率较高，而在杏仁核(P=0.004和P=0.02)和海马旁皮质(P=0.007和P=0.008)的局部有效率和局部聚集系数则较低。结论与有正常血压孕产史的对照组相比，先兆子痫妇女表现出不同的局部脑功能组织。这些功能连接方面的差异，特别是在边缘区域和前额叶皮质，与有先兆子痫病史的女性通常报告的心理和认知症状是一致的。(C)2022年提交人。超声在产科和妇科由John Wiley&Sons有限公司代表国际超声妇产科学会出版。
Objective Pre-eclampsia is a vascular complication of pregnancy, associated with a long-term risk of cerebrovascular and mental disorders. We explored whether formerly pre-eclamptic women exhibit differences in functional brain organization, especially in regions that may explain the commonly reported emotional symptoms and cognitive complaints even years after the pregnancy.Methods Formerly pre-eclamptic women and control women with a history of normotensive pregnancy underwent structural and functional 7-Tesla magnetic resonance imaging scans. Using graph theoretical analysis, the efficiency and clustering coefficient of the functional brain network were investigated. The study included local analysis focusing on particular brain structures, such as the limbic system and the prefrontal cortex, and global analysis of the whole cerebrum. Univariable and multivariable linear regression was used to investigate the relationship between brain network-related graph measures and the group (formerly pre-eclamptic or control).Results A total of 17 control parous women and 5S women with a history of pre-eclampsia were recruited. The time intervals between the index pregnancy and recruitment were 8.0 and S.6 years for the two groups, respectively. Compared with control women, formerly pre-eclamptic women had higher local efficiency in the prefrontal cortex (P = 0.048) and anterior cingulate cortex (P = 0.03) but lower local efficiency and local clustering coefficient in the amygdala (P = 0.004 and P = 0.02, respectively) and parahippocampal cortex (P = 0.007 and P = 0.008, respectively). No differences were found in the global functional brain organization.Conclusions Compared to controls with a history of normotensive pregnancy, formerly pre-eclamptic women displayed a different local functional brain organization. These differences in functional connectivity, especially in the limbic regions and the prefrontal cortex, are in line with the psychological and cognitive complaints reported commonly by women with a history of pre-eclampsia. (C) 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.