Aberrant crypts: putative preneoplastic foci in human colonic mucosa.
Aberrant crypts: putative preneoplastic foci in human colonic mucosa.
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发表时间：
1991-03
期刊：
影响因子：
11.2
通讯作者：
T. P. Pretlow;B. J. Barrow;VV. Scott Ashton;M. O'riordan;T. Pretlow;J. Jurcisek;T. Stellato
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文献类型：
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作者：
T. P. Pretlow;B. J. Barrow;VV. Scott Ashton;M. O'riordan;T. Pretlow;J. Jurcisek;T. Stellato
亚甲蓝染色后，首次在外观正常的人结肠粘膜的整装标本中发现了异常隐窝。异常隐窝的病灶从单个改变的腺体到大于30个隐窝的斑块不等。结肠癌患者的结肠黏膜改变的平均比例和每平方厘米结肠粘膜内异常隐窝的病灶数(A)高于非结肠癌或易感疾病患者，(B)在本组单个Gardner综合征患者中最高。异常隐窝被认为是结肠癌最早可识别的潜在先兆。对异常隐窝的分析可能有助于研究结肠癌发生前的早期病理和分子变化。
Aberrant crypts were identified for the first time in whole-mount preparations of normal-appearing human colonic mucosa after staining with methylene blue. The foci of aberrant crypts varied from single altered glands to plaques of greater than 30 crypts. The mean proportion of colonic mucosa altered and the number of foci with aberrant crypts per cm2 of colonic mucosa were (a) higher in patients with colon cancer than in patients without colon cancer or predisposing conditions and (b) highest in our single case of Gardner's syndrome. Aberrant crypts are postulated to be the earliest identifiable potential precursors of colon cancer. Analysis of aberrant crypts may facilitate the study of the early pathological and molecular changes that precede colon cancer.