High-Sensitivity C-Reactive Protein and Cancer
High-Sensitivity C-Reactive Protein and Cancer
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DOI：
10.2188/jea.je20100128
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发表时间：
2011-05-01
影响因子：
4.7
通讯作者：
Sung, Joohon
中科院分区：
文献类型：
--
作者：
Lee, Seounghee;Choe, Jae-Won;Sung, Joohon
背景：高敏c反应蛋白（hs-CRP）是一种常用的炎症标志物。hs-CRP与癌症之间的关系不如hs-CRP与心血管疾病之间的关系一致。本研究利用韩国健康检查记录的大型数据库，探讨了hs-CRP与癌症之间的关系。方法：选取在某综合医院健康促进中心就诊的韩国人80781例。在3年的时间里，有729例原发部位的癌症。已知患有癌症或有可能影响hs-CRP的疾病的受试者被排除在外。结果：肿瘤患者血清hs-CRP水平（2.9 mg/L）明显高于非肿瘤患者（1.4 mg/L, P < 0.0001）。hs-CRP最低类别（3mg /L），第二高类别调整后的ORs为1.16 (95% CI = 0.95-1.42)，最高类别调整后的ORs为1.94 （95% CI = 1.51-2.51）。在排除检查后1年内发现的癌症病例后，相关性仍然存在，尽管癌症病例数的减少（n = 88）减弱了相关性的显著性。结论：血清hs-CRP与癌症风险呈正相关，尽管在本横断面研究中无法推断因果关系。研究结果支持了慢性炎症在癌症中起作用的假设。
Background: High-sensitivity C-reactive protein (hs-CRP) is a commonly used inflammatory marker. The association between hs-CRP and cancer is less consistent than that between hs-CRP and cardiovascular diseases. This study explored the association between hs-CRP and cancer, using a large database of Korean health examination records.Methods: A total of 80 781 Koreans who visited the health promotion center of a general hospital were included. There were 729 cases of cancer of any primary site during a 3-year period. Subjects with a known cancer or a condition capable of affecting hs-CRP were excluded.Results: Serum hs-CRP was significantly higher in cancer cases (2.9 mg/L) than in non-cases (1.4 mg/L; P < 0.0001). With the lowest hs-CRP category (3 mg/L), and the adjusted ORs for cancer were 1.16 (95% CI = 0.95-1.42) for the second highest category and 1.94 (95% CI = 1.51-2.51) for the highest category. After excluding cancer cases detected within I year after the check-up, the associations remained, although the reduced number of cancer cases (n = 88) attenuated the significance of the associations.Conclusions: Serum hs-CRP was positively associated with the risk of cancer, although causality cannot be inferred in this cross-sectional study. The results support the hypothesis that chronic inflammation plays a role in cancer.