Novel antiplatelet naphthalene from Rhamnus nakaharai
Novel antiplatelet naphthalene from Rhamnus nakaharai
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DOI：
10.1021/np50126a023
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发表时间：
1995-12-01
影响因子：
5.1
通讯作者：
Teng, CM
中科院分区：
文献类型：
--
作者：
Li, CN;Lu, CM;Teng, CM
从黄鼠(Rhamnus Nakaharai)树皮中分离得到一种新的萘衍生物异黄酮类化合物[1]和几个已知化合物。以洗涤的兔血小板为实验对象，研究了异黄酮组分[1]、过醋酸异黄酮组[2]、6-甲氧基索热素组[3]、槲皮素3-O-甲基醚组[4]和高氧甲醚组[5]的抗血小板作用。在剩余的化合物中，1、2、4和5对花生四烯酸(AA-)和胶原诱导的血小板聚集有很强的抗血小板作用。化合物5对血小板活化因子(PAF)诱导的血小板聚集也有明显的抑制作用。本文还研究了异黄酮组[1]及其过氧乙酸酯组[2]在人富含血小板血浆(PRP)中的抗血小板活性，发现它们都能有效地抑制肾上腺素诱导的二次聚集。1和2的抗血小板作用部分是由于抑制血栓烷的形成。
A new naphthalene derivative, isotorachrysone [1], was isolated from the stem bark of Rhamnus nakaharai along with several known compounds. The antiplatelet effects of isotorachrysone [1], isotorachrysone peracetate [2], 6-methoxysorigenin [3], quercetin 3-O-methyl ether [4], and quercetin 3-O-methyl ether peracetate [5] were studied using washed rabbit platelets. Of the compounds rested, 1, 2, 4, and 5 showed potent antiplatelet effects on arachidonic acid (AA-) and collagen-induced platelet aggregation. Compound 5 also showed potent antiplatelet, effects on platelet-activating factor-(PAF-) induced platelet aggregation. Isotorachrysone [1] and its peracetate [2] were also studied for antiplatelet activity in human platelet-rich plasma (PRP) and both showed potent inhibition of the secondary aggregation induced by epinephrine. The antiplatelet effects of 1 and 2 are due partially co an inhibitory effect on thromboxane formation.