The role of the interleukin-1 receptor antagonist in blocking inflammation mediated by interleukin-1
The role of the interleukin-1 receptor antagonist in blocking inflammation mediated by interleukin-1
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DOI：
10.1056/nejm200009073431011
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发表时间：
2000-09-07
影响因子：
158.5
通讯作者：
Dinarello, CA
中科院分区：
文献类型：
--
作者：
Dinarello, CA
涉及阻断炎症细胞因子（例如白介素-1 和肿瘤坏死因子 α (TNF-α)）的方法正在进入主流临床医学：抗 TNF-α 的抗体和 TNF-α 可溶性受体正在用于治疗类风湿性关节炎和克罗恩病。大量的临床前研究构成了这些基于抗细胞因子的疗法的科学基础。在诱发涉及多种细胞因子的疾病的动物实验中，施用中和抗体或使用其他方法来阻断特定细胞因子的生物活性可减轻疾病的影响或阻止其进展。 。 。
Approaches involving the blockade of inflammatory cytokines such as interleukin-1 and tumor necrosis factor α (TNF-α) are entering mainstream clinical medicine: antibodies against TNF-α and soluble receptors for TNF-α are being used to treat rheumatoid arthritis and Crohn's disease. A large number of preclinical studies form the scientific basis for these anticytokine-based therapies. In experiments in animals in which a disease involving several cytokines has been induced, administration of neutralizing antibodies or the use of other means to block the biologic activity of a specific cytokine attenuates the effects of the disease or halts its progression.A novel approach to . . .