Temporal Proximity Promotes Integration of Overlapping Events.
Temporal Proximity Promotes Integration of Overlapping Events.
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DOI：
10.1162/jocn_a_01116
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发表时间：
2017-08
影响因子：
3.2
通讯作者：
Preston AR
中科院分区：
文献类型：
--
作者：
Zeithamova D;Preston AR
具有重叠元素的事件可以编码为两个单独的表示或链接成一个集成表示；然而，我们对促使一种代表形式优于另一种代表形式的条件知之甚少。在这里，我们测试了重叠事件的接近性会增加整合概率的假设。参与者首先建立了房屋对象和面孔对象对的记忆；其中一半是在功能性核磁共振检查前24小时学习，另一半是在检查前30分钟学习。在扫描过程中，参与者对与当天或前一天获得的初始配对重叠的对象-对象配对进行编码。当参与者对同一天或不同日所学到的重叠对之间的关系做出推理判断时，他们也会被扫描。参与者在推断当天学到的记忆之间的关系时，比推断多日获得的记忆之间的关系更准确、更快，这表明时间上的接近促进了整合。现有记忆重新激活的证据——通过视觉内容分类器测量——在编码来自两种时间条件的重叠对时是相同的。相比之下，通过独立研究（NeuroImage 124, 323-335）的助记策略分类器测量，整合的证据在同一天重叠的事件中更大，与行为结果平行。在推理过程中，当参与者对同一天获得的事件和跨天获得的事件进行推理时，激活模式进一步分化。这些发现表明，事件的时间接近性促进了整合，并进一步影响了推理过程中参与的神经机制。
Events with overlapping elements can be encoded as two separate representations or linked into an integrated representation; yet, we know little about the conditions that promote one form of representation over the other. Here, we tested the hypothesis that the proximity of overlapping events would increase the probability of integration. Participants first established memories for house-object and face-object pairs; half of the pairs were learned 24 hours before a functional MRI session, and the other half 30 minutes before the session. During scanning, participants encoded object-object pairs that overlapped with the initial pairs acquired on the same or prior day. Participants were also scanned as they made inference judgments about the relationships among overlapping pairs learned on the same or different day. Participants were more accurate and faster when inferring relationships among memories learned on the same day relative to those acquired across days, suggesting that temporal proximity promotes integration. Evidence for reactivation of existing memories—as measured by a visual content classifier—was equivalent during encoding of overlapping pairs from the two temporal conditions. In contrast, evidence for integration—as measured by a mnemonic strategy classifier from an independent study (, NeuroImage 124, 323–335)—was greater for same day overlapping events, paralleling the behavioral results. During inference itself, activation patterns further differentiated when participants were making inferences about events acquired on the same day versus across days. These findings indicate that temporal proximity of events promotes integration and further influences the neural mechanisms engaged during inference.