Metastable Fe/S clusters. The synthesis, electronic structure, and transformations of the [Fe6S6(L)6]3' clusters (L=Cl', Br', I', RS', RO') and the structure of [(C2H5)4N]3[Fe6S6Cl6]
Metastable Fe/S clusters. The synthesis, electronic structure, and transformations of the [Fe6S6(L)6]3' clusters (L=Cl', Br', I', RS', RO') and the structure of [(C2H5)4N]3[Fe6S6Cl6]
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亚稳态 Fe/S 团簇。
DOI：
10.1021/ja00290a034
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发表时间：
1985
影响因子：
15
通讯作者：
D. Coucouvanis
中科院分区：
文献类型：
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作者：
M. Kanatzidis;W. Hagen;W. Dunham;R. Lester;D. Coucouvanis
结论 本研究对 Cp2MCl2 化合物（M= Ti、V、Zr）的水化学进行了定量物理化学分析。这些化合物的氯化物水解已被证明比本研究的参考化合物顺铂更快、更广泛，尽管从两类化合物获得的数据可以使用基本相同的平衡模型进行分析。这两类化合物的水解行为之间的主要区别在于，对于 Cp2MCl2 配合物，另一个并发过程（即环戊二烯化物的损失）可能变得很重要，具体取决于 M 的性质和溶液 pH 值。在 M= Ti 的情况下，在生理 pH 下环损失很严重，而 Cp2VCl2 则没有观察到环损失。由于这两种化合物都具有抗肿瘤活性，因此对其作用机制的任何讨论都必须考虑到这一点
Conclusions This study presents a quantitative physicochemical analysis of the aqueous chemistry of the Cp2MCl2 compounds (M= Ti, V, Zr). The chloride hydrolysis of these compounds has been shown to be both more rapid and more extensive thanthat of the reference compound for this study, cisplatin, although the data obtained from both classes of compounds can be analyzed with essentially the same equilibrium model. A key difference between the hydrolysis behavior of these two classes of compounds is that for the Cp2MCl2 complexes, another concurrent process, namely loss of cyclopentadienide, can become important depending upon the nature of M and the solutionpH. In the case where M= Ti, ring loss is extensive at physiologicalpH, while it is not observed with Cp2VCl2. Since both of these compounds are antitumor active, any discussion of their mechanism of action must take this ob-