Clinical Outcome of Twice-Weekly Hemodialysis Patients in Shanghai
Clinical Outcome of Twice-Weekly Hemodialysis Patients in Shanghai
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DOI：
10.1159/000334634
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发表时间：
2012-01-01
影响因子：
3
通讯作者：
Qian, Jiaqi
中科院分区：
文献类型：
--
作者：
Lin, Xinghui;Yan, Yucheng;Qian, Jiaqi
背景：每周两次的血液透析（HD）在发展中国家很普遍，该人群的临床结果仍有待阐明。方法：数据来自上海市肾脏病登记处。 2007年1月在上海接受常规HD的2,572名患者被纳入队列研究并进行2年随访。利用从网络获得的临床和 HD 参数来比较每周两次 HD 与每周三次 HD。结果：与每周三次 HD 的患者相比，每周两次 HD 的患者明显更年轻，HD 疗程时间明显更长，单池 Kt/V (spKt/V) 更高，但 HD 周期更短 (p < 0.001)。 Kaplan-Meier 生存分析表明两组的生存率相似。多变量 Cox 回归分析显示，年龄、体重指数、血清白蛋白和每周 Kt/V 是患者死亡率的预测因素。结论：每周两次 HD 和每周三次 HD 的相似生存率可能与患者选择有关；每周两次 HD 透析的充分性仍有待阐明。版权所有 (C) 2011 S. Karger AG，巴塞尔
Background: Twice-weekly hemodialysis (HD) is prevalent in the developing countries and the clinical outcome of this population remains to be elucidated. Methods: Data were collected from Shanghai Renal Registry. 2,572 patients undergoing regular HD in Shanghai on January 2007 were enrolled into the cohort study with 2 years' follow-up. Clinical and HD parameters obtained from the network were utilized to compare twice-weekly with thrice-weekly HD. Results: Compared with patients on thrice-weekly HD, the twice-weekly HD patients were significantly younger and had significantly longer HD session time, higher single-pool Kt/V (spKt/V) but shorter HD vintage (p < 0.001). Kaplan-Meier survival analysis indicated that the two groups had similar survival. Multivariate Cox regression analysis showed that age, body mass index, serum albumin and weekly Kt/V were predictors of patient mortality. Conclusions: The similar survival between twice-weekly HD and thrice-weekly HD is likely relating to patient selection; dialysis adequacy of twice-weekly HD remains to be elucidated. Copyright (C) 2011 S. Karger AG, Basel