Global patterns and trends in the incidence of non-Hodgkin lymphoma
Global patterns and trends in the incidence of non-Hodgkin lymphoma
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DOI：
10.1007/s10552-019-01155-5
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发表时间：
2019-05-01
影响因子：
2.3
通讯作者：
Bray, Freddie
中科院分区：
文献类型：
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作者：
Miranda-Filho, Adalberto;Pineros, Marion;Bray, Freddie
目的尽管越来越多的非霍奇金淋巴瘤（NHL）的病理学和遗传学的理解，NHL的发病率的变化的全球报告仍然是有限的，在其数量和scope.Methods提供一个情况分析，国家发病率估计NHL在185个国家的2018年从GLOBOCAN数据库。我们还使用记录的发病率数据从癌症发病率在五大洲（CI 5）加上多年的诊断1980-2012检查时间trends.Results NHL排名第5至第9位最常见的癌症在世界上大多数国家，2018年估计有近510，000例新发病例。2008-2012年观察到的NHL发病率因世界地区而异：在男性中，以色列犹太人的发病率最高[年龄标准化（世界）率为17.6/100，000），澳大利亚（15.3），美国白人（14.5），加拿大（13.7）和葡萄牙（13.3）]。在数据可用，大多数人群表现出稳定或略有增加的发病率，在北美，欧洲部分地区，大洋洲的发病率上升，一般观察到，直到20世纪90年代，与此后看到的稳定。结论显着的变化，NHL发病率仍然在世界各地区的人群。应特别注意对地方性感染和环境暴露的作用进行进一步的病因学研究，特别是在非洲、亚洲和拉丁美洲。为了使统计数据具有国际可比性，还需要同等重视基于人群的登记研究中血液学信息的质量。
Purpose Despite an increasing understanding of the pathology and genetics of non-Hodgkin lymphoma (NHL), global reports on variations in the incidence of NHL remain limited in their number and scope.Methods To provide a situation analysis, national incidence estimates for NHL in 185 countries for the year 2018 were obtained from the GLOBOCAN database. We also used recorded incidence data from Cancer Incidence in Five Continents (CI5) plus for years of diagnosis 1980-2012 to examine temporal trends.Results NHL ranked as the 5th to 9th most common cancer in most countries worldwide, with almost 510,000 new cases estimated in 2018. Observed incidence rates of NHL 2008-2012 varied markedly by world region: among males, rates were highest among Israel Jews [age-standardized (world) rate of 17.6 per 100,000), Australia (15.3), US whites (14.5), Canada (13.7), and Portugal (13.3)]. Where data were available, most populations exhibited stable or slightly increasing incidence rates; in North America, parts of Europe, and Oceania the rising incidence rates were generally observed until the 1990s, with a stabilization seen thereafter.Conclusion Marked variations in NHL incidence rates remain in populations in each world region. Special attention should be given to further etiological research on the role of endemic infections and environmental exposures, particularly in Africa, Asia, and Latin America. To permit internationally comparable statistics, an equal focus on addressing the quality of hematological information in population-based registries is also warranted.