ENDOTHIOPEPTIDES
ENDOTHIOPEPTIDES
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DOI：
10.1016/s0040-4020(01)91869-1
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发表时间：
1983-01-01
期刊：
影响因子：
2.1
通讯作者：
WALKER, CV
中科院分区：
文献类型：
--
作者：
BROWN, DW;CAMPBELL, MM;WALKER, CV
使用Lawesson试剂将N-保护的二肽酯转化为相应的保护的内硫肽。定义了氨基和羧基脱保护以及硫代肽与氨基酸偶联的方法，并用于制备具有单个硫代酰胺连接的新型N-保护的内硫代三肽酯的2个实例。硫代酰胺键的构象上的二肽酯的可能影响被认为是。
N-protected dipeptide esters were converted into the corresponding protected endothiopeptides using Lawesson''s reagent. Methods of amino and carboxyl deprotection, and coupling of the thiopeptides with amino acids were defined and used to prepare 2 examples of novel N-protected endothiotripeptide esters with a single thioamide link. Possible effects of the thioamide bond on the conformation of the dipeptide esters are considered.