Factors associated with mortality in patients with tuberculosis.
Factors associated with mortality in patients with tuberculosis.
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DOI：
10.1186/1471-2334-10-258
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发表时间：
2010-08-27
影响因子：
3.7
通讯作者：
Goss CH
中科院分区：
文献类型：
--
作者：
Horne DJ;Hubbard R;Narita M;Exarchos A;Park DR;Goss CH
已知的结核病诊断后死亡的风险因素可能不适用于目前的美国病例。我们评估了与华盛顿州结核病患者全因死亡率相关的因素。利用来自华盛顿州结核病信息管理系统的数据，我们对1993年至2005年诊断为结核病的所有居民进行了一项队列研究。通过华盛顿州死亡证明数据文件确定任何原因导致的死亡。比例风险模型用于估计人口统计学、临床和行为特征对全因死亡率的独立影响。在对3451名接受结核病治疗的患者进行中位6年的随访期间，有417人死亡。死亡率与年龄增长、男性、HIV合并感染和美国出生独立相关。在结核病诊断后1年内，私人提供者的治疗和直接观察治疗的使用也与死亡率增加独立相关。此外，私人提供者直接观察治疗次数的交互作用项也与死亡率显著相关。我们确定了与结核病诊断后全因死亡率增加独立相关的因素。死亡率和供应商类型之间的关联应进行评估，更彻底的疾病严重程度的调整，但建议未来的研究的重要方向。
Known risk factors for death following a diagnosis of tuberculosis may not be applicable to current U.S. cases. We evaluated the factors associated with all-cause mortality in patients with tuberculosis in Washington State. Using data from the Tuberculosis Information Management System of Washington State, we conducted a cohort study of all residents diagnosed with tuberculosis from 1993 through 2005. Death from any cause was ascertained through the Washington State Death Certificate Data Files. Proportional hazards models were used to estimate the independent effect on all-cause mortality of demographic, clinical, and behavioral characteristics. During a median follow-up of 6 years in 3451 patients treated for tuberculosis, there were 417 deaths. Mortality was independently associated with increasing age, male gender, HIV-coinfection, and U.S. birth. Within 1 year of tuberculosis diagnosis, treatment by a private provider and the use of directly observed therapy were also independently associated with increased mortality. In addition, an interaction term of private provider times directly observed therapy was also significantly associated with mortality. We identified factors independently associated with increased all-cause mortality following a diagnosis of tuberculosis. The associations between mortality and provider type should be evaluated with more thorough adjustment for severity of illness, but suggest important directions for future research.
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影响因子：
5.8
作者：
Caylà JA;Rodrigo T;Ruiz-Manzano J;Caminero JA;Vidal R;García JM;Blanquer R;Casals M;Working Group on Completion of Tuberculosis Treatment in Spain (Study ECUTTE)
通讯作者：
Working Group on Completion of Tuberculosis Treatment in Spain (Study ECUTTE)
影响因子：
11.8
作者：
Driver, CR;Munsiff, SS;Osahan, SS
通讯作者：
Osahan, SS
影响因子：
120.7
作者：
Dye, C;Scheele, S;Raviglione, RC
通讯作者：
Raviglione, RC
影响因子：
120.7
作者：
PablosMendez, A;Sterling, TR;Frieden, TR
通讯作者：
Frieden, TR
影响因子：
158.5
作者：
WEIS, SE;SLOCUM, PC;FORESMAN, BH
通讯作者：
FORESMAN, BH