Measurement of bulk mechanical properties of tissue using laser speckle rheology.
Measurement of bulk mechanical properties of tissue using laser speckle rheology.
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DOI：
10.1109/iembs.2011.6091422
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Nadkarni SK
中科院分区：
文献类型：
--
作者：
Hajjarian Z;Nadkarni SK
几乎在所有组织中，疾病进展都伴随着机械性能的变化。激光散斑流变学 (LSR) 是我们开发的一项用于测量组织机械性能的新技术。通过用相干激光照射样品并根据反射的激光散斑图案计算散斑强度调制，LSR 计算出 τ，即与组织机械特性密切相关的强度去相关的衰减时间常数。在本文中，我们验证了 LSR 技术在测量组织机械性能中的使用。对各种体模和组织样本进行 LSR 测量 τ，并与使用流变仪测量的复数剪切模量 G* 进行比较。在所有情况下，τ 和 G* 之间都观察到很强的相关性（r=0.95，p<0.002）。这些结果证明了 LSR 作为一种非侵入式、非接触式技术对生物样品进行机械评估的有效性。
In virtually all tissues, disease progression is accompanied by changes in the mechanical properties. Laser speckle rheology (LSR) is a new technique we have developed to measure the mechanical properties of tissue. By illuminating the sample with coherent laser light and calculating the speckle intensity modulations from reflected laser speckle patterns, LSR calculates τ, the decay time constant of intensity decorrelation which is closely associated with tissue mechanical properties. In this paper we validate the use of LSR technology in measuring mechanical properties of tissue. LSR measurements of τ are performed on a variety of phantom and tissue samples and compared with the complex shear modulus G*, measured using a rheometer. In all cases, strong correlation is observed between τ and G* (r=0.95, p<0.002). These results demonstrate the efficacy of LSR as a non-invasive and non-contact technology for mechanical evaluation of biological samples.