Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: Evidence of a decreased risk of infection
Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: Evidence of a decreased risk of infection
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DOI：
10.4269/ajtmh.1997.57.37
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发表时间：
1997-07-01
影响因子：
3.3
通讯作者：
Stephensen, CB
中科院分区：
文献类型：
--
作者：
Park, JY;Peters, CJ;Stephensen, CB
淋巴细胞性脉络丛脑膜炎病毒（LCMV）是一种沙粒病毒，可引起人类疾病，从轻微的流感样疾病到脑膜炎。感染主要发生在家里和周围，由于接触受感染的老鼠。关于美国LCMV感染发生率的数据很少，但表明在过去的30-40年中感染的风险可能已经降低。为了检验这一假设，采用ELISA法检测了来自亚拉巴马伯明翰医院患者年龄分层样本的血清中的LCMV抗体。LCMV特异性IgG的总体患病率为3.5%（1，600人中有56人）。< 30岁人群抗体阳性率为0.3%（2/600），而30岁及以上人群抗体阳性率为5.4%（P < 0.0001）。采用多元逻辑回归分析确定LCMV血清阳性的危险因素。年龄与阳性抗体检测结果呈正相关（P < 0.0001），社会经济地位与阳性抗体检测结果呈负相关（P < 0.03）。这些数据与过去30-40年伯明翰人LCMV感染发病率下降一致。
Lymphocytic choriomeningitis virus (LCMV) is an arenavirus that causes human disease ranging from a mild, flu-like illness to meningitis. Infections occur principally in and around the home due to contact with infected mice. Data on the incidence of LCMV infection in the United States are scarce but suggest that the risk of infection may have decreased over the past 30-40 years, To examine this hypothesis, sera from an age-stratified sample of hospital patients in Birmingham, Alabama were tested for LCMV antibody by ELISA. The overall prevalence of LCMV-specific IgG was 3.5% (56 of 1,600). The prevalence of antibody among those < 30 years of age was 0.3% (2 of 600), while the prevalence among those 30 years of age and older was 5.4% (P < 0.0001). Multiple logistic regression was used to identify risk factors for LCMV seropositivity. Age was positively associated (P < 0.0001) and socioeconomic status was negatively associated with a positive antibody test result (P < 0.03). These data are consistent with a decreased incidence of human LCMV infection in Birmingham over the past 30-40 years.