Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis
Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis
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DOI：
10.1007/s004140100240
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发表时间：
2002-02-01
影响因子：
2.1
通讯作者：
Ludes, B
中科院分区：
文献类型：
--
作者：
Cirimele, V;Kintz, P;Ludes, B
一名44岁的麻醉科女护士被发现死在家中。在尸体附近发现了一个空的Hypnovel瓶（咪达唑仑5mg / 5ml）和一个皮下注射器。这名护士多年来滥用麻醉剂是出了名的。通过FPIA、GC/MS、顶空GC/MS和HPLC/DAD对一般未知物质进行全面筛选，发现股血中同时存在咪达唑仑、异丙酚和乙醇。对一根6厘米长的发丝进行的片段分析显示，在每根2厘米长的发丝中都存在咪达唑仑和异丙酚。因此，在死亡前的最后6个月里反复使用了这两种麻醉剂。在阴毛和腋毛中也检测到这些化合物。在没有呼吸辅助和医疗控制的情况下自行服用咪达唑仑和异丙酚肯定是导致死亡的原因。
A 44-year-old female nurse in a department of anesthesiology was found dead at home. An empty bottle of Hypnovel (midazolam 5 mg/5 ml) and a hypodermic syringe were found near the corpse. The nurse was a known abuser of anaesthetic agents for many years. A complete screening for general unknown substances by FPIA, GC/MS, head space GC/MS and HPLC/DAD revealed the simultaneous presence of midazolam, propofol and ethanol in femoral blood. Segmental analysis of a 6-cm-long hair strand revealed the presence of midazolam and propofol in each 2-cm-long segment. Repetitive consumption of the two anaesthetic agents during the last 6 months before the death was therefore demonstrated. These compounds were also detected in pubic and axillary hairs. Self-administration of midazolam and propofol without respiratory assistance and medical control certainly contributed to the death.