Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome
Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome
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DOI：
10.1016/s0304-3940(02)01058-3
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发表时间：
2003-01-02
影响因子：
2.5
通讯作者：
Giamberardino, MA
中科院分区：
文献类型：
--
作者：
Vecchiet, J;Cipollone, F;Giamberardino, MA
对21例慢性疲劳综合征(CFS)患者和20例正常人的氧化/抗氧化平衡及其与肌肉症状的相关性进行了研究。与对照组相比，患者表现为较低的延迟期和血浆维生素E(VitE)浓度、低密度脂蛋白(LDL)浓度、较高的LDL硫代巴比妥酸反应物质(TBARS)浓度、较高的疲劳感和较低的电刺激肌肉痛阈值。疲劳与TBARS、阈值与滞后期、阈值与血浆维生素E及低密度脂蛋白呈显著的直线正相关。疲劳与延迟期、疲劳与维生素E、阈值与TBARS呈显著负相关。氧化应激增加和抗氧化防御能力降低与CFS的症状程度有关，提示补充抗氧化剂可能会缓解综合征的肌肉症状。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
In 21 patients with chronic fatigue syndrome (CFS) versus 20 normal subjects, we investigated the oxidant/antioxidant balance and its correlation with muscle symptoms. Patients versus controls showed significantly: lower Lag Phase and Vitamin E (Vit E) concentrations in plasma and low-density lipoproteins (LDL), higher LDL thiobarbituric acid reactive substances (TBARS), higher fatigue and lower muscle pain thresholds to electrical stimulation. A significant direct linear correlation was found between fatigue and TBARS, thresholds and Lag Phase, thresholds and Vit E in plasma and LDL. A significant inverse linear correlation was found between fatigue and Lag Phase, fatigue and Vit E, thresholds and TBARS. Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.