CYTOKERATIN EXPRESSION IN NORMAL SALIVARY-GLANDS AND IN CYSTADENOLYMPHOMAS DEMONSTRATED BY MONOCLONAL-ANTIBODIES AGAINST SELECTIVE CYTOKERATIN POLYPEPTIDES
CYTOKERATIN EXPRESSION IN NORMAL SALIVARY-GLANDS AND IN CYSTADENOLYMPHOMAS DEMONSTRATED BY MONOCLONAL-ANTIBODIES AGAINST SELECTIVE CYTOKERATIN POLYPEPTIDES
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DOI：
10.1007/bf00713290
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发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
OTTO, HF
中科院分区：
文献类型：
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作者：
BORN, IA;SCHWECHHEIMER, K;OTTO, HF
使用一组针对多种选择性细胞角蛋白多肽、波形蛋白和神经胶质纤维蛋白 (GFP) 的单克隆抗体，将选择性细胞角蛋白多肽、波形蛋白和神经胶质纤维蛋白 (GFP) 在 5 例人腮腺囊腺淋巴瘤中的分布与正常人腮腺 (n=5) 和下颌下腺 (n=4) 腺体进行比较。生物素-链霉亲和素方法用于低温切片。在囊腺淋巴瘤的上皮部分和腮腺导管上皮中，免疫细胞化学发现相同的细胞角蛋白多肽No.7、8、18和19以及由单克隆抗体KS 8.58选择性标记的基底细胞，证实了囊腺淋巴瘤的上皮区室源自导管系统的假设。讨论了腮腺肌上皮细胞中细胞角蛋白、波形蛋白和 GFP 的三重表达。
The distribution of selective cytokeratin polypeptides, vimentin, and glial fibrillary protein (GFP) in 5 human cystadenolymphomas of the parotid gland was compared with normal human parotid (n=5) and submandibular (n=4) glands using a panel of monoclonal antibodies against diverse and selective cytokeratin polypeptides, vimentin and glial fibrillary protein (GFP). A biotin-streptavidin method was used on cryostat sections. The immunocytochemical finding of identical cytokeratin polypeptides Nos. 7, 8, 18 and 19 and basal cells selectively labeled by the monoclonal antibody KS 8.58, in both the epithelial part of the cystadenolymphomas and in the duct epithelium of the parotid gland, confirms the hypothesis that the epithelial compartment of cystadenolymphomas is derived from the duct system. The triple expression of cytokeratin, vimentin and GFP in myoepithelial cells of the parotid gland is discussed.