Peptide-based anticancer vaccines: The making and unmaking of a T-cell graveyard.
Peptide-based anticancer vaccines: The making and unmaking of a T-cell graveyard.
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DOI:
10.4161/onci.24743
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发表时间:
2013-07-01
期刊:
影响因子:
7.2
通讯作者:
Overwijk WW
中科院分区:
文献类型:
--
作者:
Hailemichael Y;Overwijk WW
Poorly biodegradable, incomplete Freund’s adjuvant (IFA)-based anticancer vaccines primed CD8+ T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunostimulatory molecules overcame this issue, resulting in tumor suppression. Here, we discuss the implications of these findings for the development of therapeutic anticancer vaccines.
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