Altered functional connectivity within default mode network after rupture of anterior communicating artery aneurysm.
Altered functional connectivity within default mode network after rupture of anterior communicating artery aneurysm.
复制标题
前交通动脉瘤破裂后默认模式网络内的功能连接发生改变
DOI：
10.3389/fnagi.2022.905453
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
前交通动脉（ACoA）动脉瘤破裂常导致认知功能障碍，尤其是记忆障碍。额内侧上级回（SFGmed）是默认模式网络（DMN）的一个节点，参与多种认知过程。然而，SFGmed的功能连接（FC）特征及其与认知表现的关系在ACoA动脉瘤破裂后仍然未知。在27名符合条件的患者和20名对照者中获得静息状态功能MRI（fMRI）和认知评估。分别计算单侧SFGmed和其余脑区的基于种子的FC，然后比较两组之间的强度差异。此外，我们还分析了前交通动脉瘤破裂患者FC异常与认知功能的相关性。51.9%的患者确认存在认知功能障碍。与对照组相比，患有破裂的ACoA动脉瘤的患者在SFGmed的每一侧和DMN内的主要节点之间表现出相似的FC下降，包括楔前叶、角回、扣带回皮质、左侧海马、左侧杏仁核、左侧颞极（TPO）和左侧内侧眶额皮质（mOFC）。此外，左侧SFGmed、左侧颞中回（MTG）和右侧mOFC的FC也显著降低，并且与右侧SFGmed的连接仅增强，而左侧SFGmed的FC未增强。相关性分析表明，较低的总认知表现或较强的主观记忆投诉与SFGmed和几个皮质区域（如角回和中扣带回皮质（MCC））的连接性降低有关。我们的研究结果表明，前交通动脉瘤破裂患者存在长期的认知功能障碍和DMN内认知相关脑区的内在连接低下。DMN失活可能是导致这些患者认知功能障碍的潜在神经机制。
Rupture of anterior communicating artery (ACoA) aneurysm often leads to cognitive impairment, especially memory complaints. The medial superior frontal gyrus (SFGmed), a node of the default mode network (DMN), has been extensively revealed to participate in various cognitive processes. However, the functional connectivity (FC) characteristics of SFGmed and its relationship with cognitive performance remain unknown after the rupture of the ACoA aneurysm. Resting-state functional MRI (fMRI) and cognitive assessment were acquired in 27 eligible patients and 20 controls. Seed-based FC between unilateral SFGmed and the rest of the brain was calculated separately, and then compared their intensity differences between the two groups. Furthermore, we analyzed the correlation between abnormal FC and cognitive function in patients with ruptured ACoA aneurysm. Cognitive impairment was confirmed in 51.9% of the patients. Compared with the controls, patients suffering from ruptured ACoA aneurysm exhibited a similar FC decline between each side of SFGmed and predominant nodes within DMN, including the precuneus, angular gyrus, cingulate cortex, left hippocampus, left amygdala, left temporal pole (TPO), and left medial orbitofrontal cortex (mOFC). Besides, significantly decreased FC of left SFGmed and left insula, right middle temporal gyrus (MTG), as well as right mOFC, were also found. In addition, only enhanced insular connectivity with right SFGmed was determined, whereas increased FC of the left SFGmed was not observed. Correlation analyses showed that lower total cognitive performance or stronger subjective memory complaints were related to reduced connectivity in the SFGmed and several cortical regions such as the angular gyrus and middle cingulate cortex (MCC). Our results suggest that patients with ruptured ACoA aneurysm exist long-term cognitive impairment and intrinsic hypoconnectivity of cognition-related brain regions within DMN. Deactivation of DMN may be a potential neural mechanism leading to cognitive deficits in these patients.
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无严重并发症的低级别患者前交通动脉瘤破裂治疗后的认知障碍和危险因素：一项多中心回顾性研究
影响因子：
3.4
作者：
Ma N;Feng X;Wu Z;Wang D;Liu A
通讯作者：
Liu A
DOI：
10.1073/pnas.1521083113
发表时间：
2016-07-26
影响因子：
11.1
作者：
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通讯作者：
Corbetta, Maurizio
DOI：
10.1073/pnas.1601485113
发表时间：
2016-08-02
影响因子：
11.1
作者：
Hsu, Li-Ming;Liang, Xia;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
6.8
作者：
Egorova N;Cumming T;Shirbin C;Veldsman M;Werden E;Brodtmann A
通讯作者：
Brodtmann A
影响因子：
7.4
作者：
Kim J;Shin E;Han K;Park S;Youn JH;Jin G;Lee JY
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