Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography
Imaging molecular signatures for clinical detection of scleroderma in the hand by multispectral photoacoustic elastic tomography
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DOI：
10.1002/jbio.201700267
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发表时间：
2018-06-01
影响因子：
2.8
通讯作者：
Yuan, Zhen
中科院分区：
文献类型：
--
作者：
Liu, Yubin;Zhang, Lingyan;Yuan, Zhen
硬皮病是一种少见的自身免疫性疾病，分为局限性硬皮病和全身性硬皮病。局限性SD主要导致手指皮肤增厚，而系统性SD可进一步影响血管和内脏器官。在这项试点研究中，多光谱光声弹性断层扫描（PAET）成像技术被用来恢复定量的生理和弹性的生物组织的SD诊断性能。3例健康受试者和3例SD患者由风湿科医生进行临床检查，然后用磁共振成像和自制的光声成像系统扫描他们的手/手指。使用开发的PAET重建方法重建生理参数，包括氧饱和度（STO 2），脱氧血红蛋白（Hb）和氧合血红蛋白（HbO（2））浓度和机械性能，如体积弹性模量图像。我们的成像结果表明，SD和正常手指之间的生理和弹性参数表现出显着的差异，表明这些生物标志物可以作为早期检测SD的分子特征。这些定量的生理特性和体积模量也可能为更好地理解SD的病理机制铺平了新的道路。
Scleroderma (SD) is a rare autoimmune disease, which is divided into 2 categories: the localized SD and systemic SD. The localized SD mainly causes skin thickening of the fingers, whereas the systemic SD can further affect the blood vessels and internal organs. In this pilot study, the multispectral photoacoustic elastic tomography (PAET) imaging technique was used to recover the quantitative physiological and elastic properties of biological tissues for the diagnosis of SD. Three healthy subjects and 3 SD patients were recruited and clinically examined by a rheumatologist, and then their hand/fingers were scanned by both magnetic resonance imaging and our home-made photoacoustic imaging system. Physiological parameters including oxygen saturation (STO2), deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO(2)) concentrations and mechanical properties such as bulk elastic modulus images were reconstructed using the developed PAET reconstruction method. Our imaging results demonstrated that the physiological and elastic parameters exhibit striking differences between the SD and normal fingers, indicating that these biomarkers can serve as molecular signatures for early detection of SD. These quantitative physiological properties and bulk modulus may also pave a new path for improved understanding the pathological mechanism of SD.