Estimation of optimal dynamic anticoagulation regimes from observational data: A regret-based approach
Estimation of optimal dynamic anticoagulation regimes from observational data: A regret-based approach
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DOI：
10.1002/sim.2694
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发表时间：
2006-12-30
影响因子：
2
通讯作者：
Stewart, Syd
中科院分区：
文献类型：
--
作者：
Rosthoj, Susanne;Fullwood, Catherine;Stewart, Syd
长期抗凝治疗的一个并发症是，最佳剂量水平不仅在患者之间变化，而且在患者体内随时间变化，以应对生活方式的短期变化。因此，剂量需要是自适应的，但目前还没有公认的决策规则。由于世界范围内抗凝剂的使用越来越多，因此需要更客观和常规的程序。在本文中，我们描述了观察纵向抗凝数据的分析，旨在确定一个最佳的反应剂量变化策略。我们使用Murphy（J.R. Stat. Soc. Ser B 2003; 65：331-366）。在实施的方法中遇到的实际问题进行了讨论和说明。版权所有（c）2006约翰威利父子有限公司。
A complication of long-term anticoagulation is that the optimal dose level varies not only between patients but over time within patients, in response to short-term changes in lifestyle. Consequently, doseage needs to be adaptive but there are as yet no accepted decision rules. Since anticoagulant use is increasing worldwide there is a need for more objective and routine procedures. In this paper, we describe an analysis of observational longitudinal anticoagulant data, aimed at determining an optimal reactive dose-changing strategy. We use the regret parameterization approach advocated by Murphy (J. R. Stat. Soc. Ser B 2003; 65:331-366). Practical problems encountered in the implementation of the approach are discussed and illustrated. Copyright (c) 2006 John Wiley & Sons, Ltd.