Rat liver alcohol dehydrogenase activity: effects of growth hormone and hypophysectomy.
Rat liver alcohol dehydrogenase activity: effects of growth hormone and hypophysectomy.
复制标题
大鼠肝脏乙醇脱氢酶活性：生长激素和垂体切除术的影响。
作者：
E. Mezey;J. Potter
先前证明，实验性尿毒症和应激后大鼠肝脏酒精脱氢酶的增加可能是由这些条件下发现的激素变化所调节的。本研究测定了糖皮质激素、生长激素、肾上腺切除和垂体切除对大鼠肝脏乙醇脱氢酶活性的影响。每日服用氢化可的松、皮质酮或促肾上腺皮质激素6天或切除肾上腺均不影响该酶的活性。0.02、0.2、1.0和4 mg/100gbw·d-1剂量的牛生长激素连续给药6.5d，可引起肝脏乙醇脱氢酶活性升高。小剂量0.02 mg/100gbw·d-1后，酶活性升高幅度最大。尿毒症大鼠肝脏酒精脱氢酶升高或反复束缚应激后大鼠血浆GH升高，提示GH可能在这些条件下酶活性的升高中起作用。然而，脑垂体玩具是一种。
Previously demonstrated increases in liver alcohol dehydrogenase in experimental uremia and after stress in the rat may be mediated by hormonal changes found in these conditions. In this study, the effects of corticosteroids, GH, adrenalectomy, and hypophysectomy on the activity of liver alcohol dehydrogenase in the rat were determined. Neither the daily administration of hydrocortisone, corticosterone, or corticotropin for 6 days nor adrenalectomy had any effect on the enzyme activity. Bovine GH, administered in doses of 0.02, 0.2, 1.0, and 4 mg/100 g BW-day for 6.5 days, resulted in increases in liver alcohol dehydrogenase. A maximum increase in the enzyme activity was found after the administration of the low dose of 0.02 mg/100 g BW-day. Plasma GH was found to be elevated in rats with increased liver alcohol dehydrogenase due to uremia or after repeated stress induced by immobilization; hence, GH may play a role in the elevation of the enzyme activity in these conditions. However, hypophysectoy was fo...