A Longitudinal Study of Cellular Changes in Experimental Otitis Media
A Longitudinal Study of Cellular Changes in Experimental Otitis Media
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实验性中耳炎细胞变化的纵向研究
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
S. Juhn
中科院分区：
文献类型：
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作者：
M. Goycoolea;M. Paparella;A. Carpenter;S. Juhn
使用咽鼓管阻塞对实验动物（猫）进行中耳炎的纵向连续研究。使用了五十只动物。从阻塞后一天到六个月，粘骨膜的连续变化显示出每只动物相似的逐渐变化。定义了阶段，并通过使用不同的染色技术（包括免疫细胞化学），假设并记录了整个中耳防御系统。描述了非特异性和特异性防御系统，包括局部免疫。对积液进行了连续研究，并讨论了其发病机制。
A longitudinal sequential study of otitis media in an experimental animal (cat) using eustachian tube obstruction was done. Fifty animals were used. The continuum of mucoperiosteal changes from one day to six months after obstruction revealed gradual changes that were similar for each animal. Stages were defined, and by using different staining techniques, including immunocytochemistry, an overall middle ear defense system was postulated and documented. Nonspecific as well as specific defense systems, including localized immunity, were described. Effusions were studied in a continuum, and their pathogenesis was discussed.