Kininogens are antithrombotic proteins in vivo
Kininogens are antithrombotic proteins in vivo
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DOI：
10.1161/01.atv.19.9.2245
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发表时间：
1999-09-01
影响因子：
8.7
通讯作者：
Sartor, RB
中科院分区：
文献类型：
--
作者：
Colman, RW;White, JV;Sartor, RB
最近已证明激肽原具有抗粘附、抗凝血和纤溶原特性，并且可以在低凝血酶浓度下抑制血小板活化。为了测试激肽原是否具有体内抗血栓特性，我们设计了仅限于去除内皮的有限动脉损伤模型。将因单点突变 A163T 而缺乏低分子量和高分子量激肽原的 Brown-Norway Katholiek 品系大鼠在血栓形成模型中与野生型动物进行比较，野生型动物在其他方面基因相同。尽管血管损伤相当，但通过激光多普勒测量血流减少 90% 的平均时间 (+/-SEM) 在缺乏激肽原的大鼠中为 38.4+/-17 分钟，而在野生型动物中为 194+/-29 分钟 (P
Kininogens have recently been shown to possess antiadhesive, anticoagulant, and profibrinolytic properties and can inhibit platelet activation at low thrombin concentrations. To test whether kininogens have antithrombotic properties in vivo, we devised a model of limited arterial injury confined to removal of the endothelium. Brown-Norway Katholiek strain rats with an absence of low- and high-molecular-weight kininogen due to a single point mutation, A163T, were compared in the thrombosis model to the wild-type animals, which were otherwise genetically identical. Despite an equivalent vascular injury, the mean time (+/-SEM) for a 90% decrease in flow measured by laser Doppler was 38.4+/-17 minutes in the kininogen-deficient rats compared with 194+/-29 minutes in the wild-type animals (P