In vivo sarcomere imaging and fiber tension measurements.
In vivo sarcomere imaging and fiber tension measurements.
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体内肌节成像和纤维张力测量。
DOI：
10.1109/iembs.2010.5627513
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Zhang,Li-Qun
中科院分区：
文献类型：
--
作者：
Wu,Yi-Ning;Ren,Yupeng;Zhang,Li-Qun
目前的工作展示了一种新的方法和一种新的装置，同时在体内测量肌节成像和纤维张力。肌节是肌肉的组成部分，在肌肉收缩中起着关键作用。在病理状态下，肌节和肌纤维的生物力学特性可能发生显著改变。我们开发了一种新的方法，通过结合光学图像捕获系统与力测量，使我们能够调查在监测/控制张力下的肌细胞特性在体内。该方法在体内大鼠模型中以及使用体外确证装置进行了验证。体内评价为我们研究纤维/肌节的病理变化和帮助确定适当的治疗提供了有力的工具。
Current work demonstrates a new method and a new device for simultaneous in vivo measurements of sarcomere imaging and fiber tension. Sarcomere, a building block of muscles, plays a critical role in muscle contraction. In the pathological conditions, the biomechanical properties of sarcomere and muscle fibers may be altered significantly. We developed a novel methodology by combining the optical image capture system with force measurement which allowed us to investigate the muscle cell properties in vivo under monitored/controlled tension. The methodology was validated in an in vivo rat model as well as using an in vitro corroboration setup. The in vivo evaluation provides us a powerful tool to investigate pathological changes of fibers/sarcomeres and help determine proper treatment.