Tumor suppressor activity of RUNX3
Tumor suppressor activity of RUNX3
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DOI：
10.1038/sj.onc.1207286
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发表时间：
2004-05-24
期刊：
影响因子：
8
通讯作者：
Choi, JK
中科院分区：
文献类型：
--
作者：
Bae, SC;Choi, JK
最近的分析表明，RUNX 家族成员在正常发育过程和致癌过程中发挥着重要作用。在三个已知的 RUNX 家族成员中，RUNX3 已被证明参与背根神经节的神经发生、T 细胞分化和胃上皮的肿瘤发生。小鼠中 Runx3 位点的缺失导致胃上皮增生，这是由于刺激增殖和抑制细胞凋亡，同时伴随着对 TGF-β1 敏感性的降低。在原发性人胃癌标本中，RUNX3 经常因等位基因丢失或启动子高甲基化导致的基因沉默而失活。人胃癌细胞株在裸鼠体内的致瘤性随着RUNX3表达水平的增加而降低，这表明RUNX3是一个真正的东西。 de 胃癌的肿瘤抑制因子。
Recent analyses have revealed that RUNX family members play important roles in both normal developmental processes and carcinogenesis. Of the three known RUNX family members, RUNX3 has been shown to be involved in neurogenesis of the dorsal root ganglia, T-cell differentiation and tumorigenesis of gastric epithelium. Deletion of the Runx3 locus in mice resulted in hyperplasia of the gastric epithelium due to the stimulation of proliferation and suppression of apoptosis that was accompanied by a reduced sensitivity to TGF-beta1. In primary human gastric cancer specimens, RUNX3 is frequently inactivated by allele loss or gene silencing due to promoter hypermethylation. The tumorigenicity of human gastric cancer cell lines in nude mice decreased as the level of RUNX3 expression increased, which indicates that RUNX3 is a bona. de tumor suppressor of gastric cancers.