Vesicular Self-Assembly of Colloidal Amphiphiles in Microfluidics
Vesicular Self-Assembly of Colloidal Amphiphiles in Microfluidics
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DOI：
10.1021/am4028839
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发表时间：
2013-10-09
影响因子：
9.5
通讯作者：
Nie, Zhihong
中科院分区：
文献类型：
--
作者：
He, Jie;Wang, Lei;Nie, Zhihong
微流控装置中的流体动力学流动为两亲分子的连续可控自组装提供了一个高通量平台。然而，流体力学对胶体两亲物（CAMs）组装的作用仍然没有很好的理解。本文报道了一个系统的研究CAMs组装，这是由Au纳米粒子（AuNPs）接枝与两亲性嵌段共聚物，成囊泡与单层的CAMs在膜中使用层流MF流动聚焦装置。我们的实验和模拟研究表明，溶剂和胶体的横向扩散穿过相邻的层状流的边界起着至关重要的作用，在组装成囊泡的CAM。通过调节流动的流体动力学条件，可以将囊泡的尺寸控制在100-600 nm的范围内。此外，CAM的扩散系数也是其组装的关键。在相同的流动条件下，较大的CAM生成较大的组件作为一个结果，大的两亲物的扩散速率降低。本工作为纳米囊泡的制备提供了基础指导，并可应用于生物成像、药物输送、纳米和微反应器等领域。
Hydrodynamic flow in a microfluidic (MF) device offers a high-throughput platform for the continuous and controllable self-assembly of amphiphiles. However, the role of hydrodynamics on the assembly of colloidal amphiphiles (CAMs) is still not well understood. This Article reports a systematic study of the assembly of CAMs, which consist of Au nanoparticles (AuNPs) grafted with amphiphilic block copolymers, into vesicles with a monolayer of CAMs in the membranes using laminar flows in MF flow-focusing devices. Our experimental and simulation studies indicate that the transverse diffusion of solvents and colloids across the boundary of neighboring lamellar flows plays a critical role in the assembly of CAMs into vesicles. The dimension of the vesicles can be controlled in the range of 100-600 nm by tuning the hydrodynamic conditions of the flows. In addition, the diffusion coefficient of CAMs was also critical for their assembly. Under the same flow conditions, larger CAMs generated larger assemblies as a result of the reduced diffusion rate of large amphiphiles. This work could provide fundamental guidance for the preparation of nanoparticle vesicles with applications in bioimaging, drug delivery, and nano- and microreactors.