Survival of Helicobacter pylori in gastric acidic territory.

Survival of Helicobacter pylori in gastric acidic territory.
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DOI:
10.1111/hel.12386
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发表时间:
2017-08
期刊:
影响因子:
4.4
通讯作者:
Yamaoka Y
Yamaoka Y
中科院分区:
医学2区
文献类型:
--
作者:
Ansari S;Yamaoka Y

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幽门螺杆菌很好地适应于定殖于人胃粘膜的上皮表面,并可引起持续性感染。它的致病作用包括胃炎、消化性溃疡和增加胃癌发展的风险。H. pylori必须在胃酸pH中存活。pylori具有良好的中和酸性pH的作用的机制。许多细菌因素以及环境因素的确切作用仍然没有解决,并且这些因素如何参与酸介导的细菌存活仍然未知。在这篇综述中,我们讨论和总结了各种信息发表在科学文献中的功能和分子方面,细菌可以对抗和生存的不良影响,胃酸pH值,以建立持续性感染。
Helicobacter pylori is well adapted to colonize the epithelial surface of the human gastric mucosa and can cause persistent infections. Its pathogenic effects consist of gastritis, peptic ulcers and increased risk for the development of gastric cancer. In order to infect the gastric mucosa, H. pylori has to survive in the gastric acidic pH. H. pylori has well developed mechanisms to neutralize the effects of acidic pH. The exact role of many bacterial factors as well as environmental factors still remains unsolved and how these factors involve in the acid mediated survival of bacterium is unknown yet. In this review, we have discussed and summarized the various information published in scientific literatures regarding functional and molecular aspects by which the bacterium can combat and survive the adverse effects of stomach acidic pH in order to establish the persistent infections.
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发表时间: 2012
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