Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy
Antibodies to LM1 and LM1-containing ganglioside complexes in Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy
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DOI：
10.1016/j.jneuroim.2011.08.016
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发表时间：
2011-10-28
影响因子：
3.3
通讯作者：
Kusunoki, Susumu
中科院分区：
文献类型：
--
作者：
Kuwahara, Motoi;Suzuki, Seiko;Kusunoki, Susumu
LM1 位于人周围神经髓磷脂中。据报道，格林-巴利综合征 (GBS) 中存在神经节苷脂复合物 (GSC) 抗体。我们研究了每 40 名慢性炎症性脱髓鞘性多发性神经病 (CIDP) 和 CBS 患者血清中针对 LM1 和两种 GSC（GM1 和 LM1，或 GD1b 和 LM1）的 IgG 抗体。使用 ELISA。我们用 CBS 检测到了 5 例，用 CIDP 检测到了 7 例；抗 GM1/LM1 抗体，三种使用 CBS，一种使用 CIDP；和抗GD1b/LM1抗体与CIDP分两种。 LM1 抗体和含有 LM1 的 GSC 可能是 CBS 和 CIDP 自身免疫的靶标之一。 (C) 2011 Elsevier B.V. 保留所有权利。
LM1 is localized in human peripheral nerve myelin. Antibodies to ganglioside complexes (GSCs) have been reported in Guillain-Barre syndrome (GBS). We investigated IgG antibodies to LM1 and two GSCs (GM1 and LM1, or GD1b and LM1) in the sera of each 40 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and CBS. using ELISA. We detected anti-LM1 antibody in five with CBS and seven with CIDP; anti-GM1/LM1 antibody in three with CBS and one with CIDP; and anti-GD1b/LM1 antibody in two with CIDP. Antibodies to LM1 and LM1-containing GSCs may be among the targets for autoimmunity in CBS and CIDP. (C) 2011 Elsevier B.V. All rights reserved.